Process for preparing a pharmaceutical composition

Abstract

A method for the preparation of compositions, preferably pharmaceutical compositions, in form of expanded, mechanically stable, lamellar, porous, sponge-like or foam structures out of solutions and dispersions results in a favored pharmaceutical product. This method comprises the steps of a) preparing a solution or a homogeneous dispersion of a liquid and a compound selected from the group consisting of one or more pharmaceutically active compounds, one or more pharmaceutically suitable excipients, and mixtures thereof, followed by b) the expansion of the solution or the homogeneous dispersion without boiling.

1 . A composition characterized by a coherent, lamellar, foam-, sponge- or cake-like structure, which comprises from about 0.2 to about 10% w/w residual isopropyl alcohol, about 1 to about 98.8% w/w oseltamivir, and about 1 to about 98.8% w/w polymethacrylate.  
   
   
       2 . The composition of  claim 1 , wherein the composition has a bulk (poured) density between about 0.1 and about 0.9 g/cm 3 .  
   
   
       3 . The composition of  claim 1 , wherein the composition has a particle size distribution between about 50 and about 600 μm.  
   
   
       4 . The composition of  claim 1 , wherein the composition has a residual solvent level between 0.1 and 10%.