US2006128993A1PendingUtilityA1

Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine and its formamide

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Assignee: SEPRACOR INCPriority: Sep 16, 2002Filed: Jan 24, 2006Published: Jun 15, 2006
Est. expirySep 16, 2022(expired)· nominal 20-yr term from priority
Inventors:Thomas JerussiQun Kevin FangMark G. Currie
C07C 2602/28A61P 25/08A61P 3/04A61P 25/28A61P 25/22A61P 25/14C07C 211/42A61P 25/00C07B 2200/07A61P 25/20A61P 25/16A61P 25/24A61K 31/135C07C 2602/10A61P 25/30A61P 25/06
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Claims

Abstract

Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful.

Claims

exact text as granted — not AI-modified
1 . A compound of formula PQ:  
       
         
           
           
               
               
           
         
       
       or a salt thereof.  
     
     
         2 . A compound according to  claim 1 , of formula P or Q:  
       
         
           
           
               
               
           
         
       
       or a salt thereof.  
     
     
         3 . (1S,4R)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine according to  claim 1 , or a salt thereof.  
     
     
         4 . (1R,4S)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine according to  claim 1 , or a salt thereof.

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