US2006111322A1PendingUtilityA1

Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation

Assignee: AGOURON PHARMAPriority: Jan 18, 2000Filed: Jan 10, 2006Published: May 25, 2006

Est. expiryJan 18, 2020(expired)· nominal 20-yr term from priority

Inventors:Siegfried H. Reich Ted M. Bleckman Susan Elizabeth Kephart William H. Romines Michael Brennan Wallace

A61P 35/00A61P 43/00A61P 9/00C07D 403/04C07D 233/56C07F 7/1804C07D 231/56C07D 401/14C07D 231/12C07D 471/04C07D 401/04C07D 249/08B22D 41/56

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References

Claims

Abstract

The invention is directed to intermediates useful for making indazole compounds that modulate and/or inhibit cell proliferation.

Claims

exact text as granted — not AI-modified

1 . A compound having the formula  
     
       
         
         
             
             
         
       
     
     wherein PG is (trimethyl silyl) ethoxy methyl (SEM), p-methoxybenzyl (PMB), benzyloxycarbonyl (CBZ), tert-butoxycarbonyl (BOC), tetra hydropyranyl (THP), or fluorene-9-methyloxycarbonyl; 
 T is substituted or unsubstituted boron, halo, NO 2 , or NH 2  group; and  
 T′ is CO 2 H.  
 
   
   
       2 . The compound according to  claim 1  wherein PG is SEM.  
   
   
       3 . A compound selected from the group consisting of:

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