Agaricus blazei murill extract capable for preventing cancer induction or metastasis

Abstract

A foodstuff capable of preventing the induction or metastasis of cancer is provided. In particular, an Agaricus blazei Murill extract comprising an ingredient capable of preventing the induction or metastasis of cancer is provided. The ingredient can be a chromatographic main elute fraction of 100 to 2000 molecular weight, obtained by the steps of extracting the fruit body of Agaricus blazei Murill with hot water, dialyzing the resultant extract, and subjecting the thus obtained dialysis external fluid to chromatography. Alternatively, the ingredient can be a dialysis external fluid obtained by the steps of extracting the fruit body of Agaricus blazei Murill with hot water, adding ethanol to the resultant extract to thereby obtain precipitates, dissolving the precipitates in water, and dialyzing the solution.

1 . An extact from  agaricus , which comprises an ingredient being capable of preventing induction or metastasis of cancer.  
   
   
       2 . The extract according to  claim 1 , wherein the extract is prepared by solvent extraction.  
   
   
       3 . The extract according to  claim 2 , wherein the extract is prepared by extraction with hot water.  
   
   
       4 . The extract according to  claim 1 , wherein the ingredient is a chromatographic main elute fraction of 100 to 2000 molecular weight obtained by the steps of extracting the fruit body of  agaricus  with hot water, dialyzing the resultant extract, and subjecting the thus obtained dialysis external fluid to chromatography.  
   
   
       5 . The extract according to  claim 1 , wherein the ingredient is a dialysis external fluid obtained by the steps of extracting the fruit body of  agaricus  with hot water, adding ethanol to the resultant extract to thereby obtain precipitates, dissolving the precipitates in water, and dialyzing the solution.  
   
   
       6 . The extract according to  claim 1 , wherein the cancer is induced by urethane, (4-N-methyl-N-nitroamino)-1-(3-pyridyl)-1-buthanone or azoxymethane.  
   
   
       7 . The extract according to  claim 1 , wherein the cancer is lung cancer.  
   
   
       8 . The extract according to  claim 1 , wherein the cancer is large intestine cancer.  
   
   
       9 . A composition being capable of preventing induction or metastasis of cancer, which comprises an  agaricus  extract, and a pharmaceutically acceptable carrier.  
   
   
       10 . The composition according to  claim 9 , wherein the composition is in a form selected from the group consisting of powder, liquid, tablet, capsule and pellet.  
   
   
       11 . Use of an  agaricus  extract for preparing a composition being capable of preventing induction or metastasis of cancer.