Combination

Abstract

The present invention relates to a combination, especially a pharmaceutical composition, comprising as active ingredients (i) an AT 1 -receptor antagonist or a pharmaceutically acceptable salt thereof; (ii) (a) an insulin secretion enhancer or a pharmaceutically acceptable salt thereof or (b) an insulin sensitizer or a pharmaceutically acceptable salt thereof; and, in case of a pharmaceutical composition, a pharmaceutically acceptable carrier.

1 . A pharmaceutical composition, wherein the active ingredients consist of 
 (i) an AT 1 -receptor antagonist or a pharmaceutically acceptable salt thereof;    (ii) (a) an insulin secretion enhancer or a pharmaceutically acceptable salt thereof or 
 (b) an insulin sensitizer or a pharmaceutically acceptable salt thereof; and  
   (iii) a pharmaceutically acceptable carrier.    
   
   
       2 . A compostion acording to  claim 1  wherein the AT 1  receptor antagonist is selected from the group consisting of valsartan, losartan, candesartan, eprosartan, irbesartan, olmesartan, tasosartan, and telmisartan, and, in each case, a pharmaceutically acceptable salt thereof.  
   
   
       3 . A composition according to  claim 2  wherein the AT 1  receptor antagonist is valsartan or a pharmaceutically acceptable salt thereof.  
   
   
       4 . A composition according to  claim 1  wherein the insulin secretion enhancer is selected from tolbutamide; chlorpropamide; tolazamide; acetohexamide; glycopyramide; glibenclamide; gliclazide; 1-butyl-3-metanilylurea; carbutamide; glibonuride; glipizide; gliquidone; glisoxepid; glybuthiazole; glibuzole; glyhexamide; glymidine; glypinamide; phenbutamide; tolylcyclamide, nateglinide repaglinide; mitiglinide; glimepiride; and, in each case, a pharmaceutically acceptable salt thereof.  
   
   
       5 . A composition according to  claim 4  wherein the insulin secretion enhancer is nateglinide or a pharmaceutically acceptable salt thereof.  
   
   
       6 . A composition according to  claim 1  wherein the insulin sensitizer is metformin or a pharmaceutically acceptable salt thereof.  
   
   
       7 . A composition according to  claim 1  for the prevention, delay of progression or treatment of a of disease or disorder selected from the group consisting of hypertension, congestive heart failure, diabetes, especially type 2 diabetes mellitus, diabetic retinopathy, macular degeneration, diabetic nephropathy, glomerulosclerosis, chronic renal failure, diabetic neuropathy, syndrome X, premenstrual syndrome, coronary heart disease, angina pectoris, myocardial infarction, stroke, vascular restenosis, hyperglycemia, hyperinsulinaemia, hyperlipidaemia, hypertryglyceridemia, insulin resistance, impaired glucose metabolism, conditions of impaired glucose tolerance (IGT), conditions of impaired fasting plasma glucose, obesity, diabetic retinopathy, macular degeneration, cataracts, diabetic nephropathy, glomerulosclerosis, diabetic neuropathy, erectile dysfunction, skin and connective tissue disorders, foot ulcerations and ulcerative colitis, endothelial dysfunction and impaired vascular compliance.  
   
   
       8 . A composition according to  claim 1  for the prevention, delay of progression or treatment of a of disease or disorder selected from the group consisting of hypertension, especially ISH, congestive heart failure, endothelial dysfunction, impaired vascular compliance, IGT and type II diabetes mellitus.  
   
   
       9 . A method for the prevention, delay of progression or treatment of a disease or disorder which may be inhibited by the inhibition of AT 1  receptor and/or by the enhancement of insulin secretion comprising administering to a warm-blooded animal, including man, in need thereof jointly therapeutically effective amounts of 
 (i) an AT 1 -receptor antagonist or a pharmaceutically acceptable salt thereof;    (ii) (a) an insulin secretion enhancer or a pharmaceutically acceptable salt thereof or 
 (b) an insulin sensitizer or a pharmaceutically acceptable salt thereof.  
   
   
   
       10 . Use of a combination comprising as active ingredients 
 (i) an AT 1 -receptor antagonist or a pharmaceutically acceptable salt thereof;    (ii) (a) an insulin secretion enhancer or a pharmaceutically acceptable salt thereof or 
 (b) an insulin sensitizer or a pharmaceutically acceptable salt thereof;  
   for the manufacture of a medicament for the prevention, delay of progression or treatment of a disease or disorder which may be inhibited by the inhibition of AT 1  receptor and by the enhancement of insulin secretion.    
   
   
       11 . The composition according to  claim 2  for the prevention, delay of progression or treatment of a of disease or disorder selected from the group consisting of hypertension, congestive heart failure, diabetes, especially type 2 diabetes mellitus, diabetic retinopathy, macular degeneration, diabetic nephropathy, glomerulosclerosis, chronic renal failure, diabetic neuropathy, syndrome X, premenstrual syndrome, coronary heart disease, angina pectoris, myocardial infarction, stroke, vascular restenosis, hyperglycemia, hyperinsulinaemia, hyperlipidaemia, hypertryglyceridemia, insulin resistance, impaired glucose metabolism, conditions of impaired glucose tolerance (IGT), conditions of impaired fasting plasma glucose, obesity, diabetic retinopathy, macular degeneration, cataracts, diabetic nephropathy, glomerulosclerosis, diabetic neuropathy, erectile dysfunction, skin and connective tissue disorders, foot ulcerations and ulcerative colitis, endothelial dysfunction and impaired vascular compliance.  
   
   
       12 . The composition according to  claim 3  for the prevention, delay of progression or treatment of a of disease or disorder selected from the group consisting of hypertension, congestive heart failure, diabetes, especially type 2 diabetes mellitus, diabetic retinopathy, macular degeneration, diabetic nephropathy, glomerulosclerosis, chronic renal failure, diabetic neuropathy, syndrome X, premenstrual syndrome, coronary heart disease, angina pectoris, myocardial infarction, stroke, vascular restenosis, hyperglycemia, hyperinsulinaemia, hyperlipidaemia, hypertryglyceridemia, insulin resistance, impaired glucose metabolism, conditions of impaired glucose tolerance (IGT), conditions of impaired fasting plasma glucose, obesity, diabetic retinopathy, macular degeneration, cataracts, diabetic nephropathy, glomerulosclerosis, diabetic neuropathy, erectile dysfunction, skin and connective tissue disorders, foot ulcerations and ulcerative colitis, endothelial dysfunction and impaired vascular compliance.  
   
   
       13 . The composition according to  claim 4  for the prevention, delay of progression or treatment of a of disease or disorder selected from the group consisting of hypertension, congestive heart failure, diabetes, especially type 2 diabetes mellitus, diabetic retinopathy, macular degeneration, diabetic nephropathy, glomerulosclerosis, chronic renal failure, diabetic neuropathy, syndrome X, premenstrual syndrome, coronary heart disease, angina pectoris, myocardial infarction, stroke, vascular restenosis, hyperglycemia, hyperinsulinaemia, hyperlipidaemia, hypertryglyceridemia, insulin resistance, impaired glucose metabolism, conditions of impaired glucose tolerance (IGT), conditions of impaired fasting plasma glucose, obesity, diabetic retinopathy, macular degeneration, cataracts, diabetic nephropathy, glomerulosclerosis, diabetic neuropathy, erectile dysfunction, skin and connective tissue disorders, foot ulcerations and ulcerative colitis, endothelial dysfunction and impaired vascular compliance.  
   
   
       14 . The composition according to  claim 5  for the prevention, delay of progression or treatment of a of disease or disorder selected from the group consisting of hypertension, congestive heart failure, diabetes, especially type 2 diabetes mellitus, diabetic retinopathy, macular degeneration, diabetic nephropathy, glomerulosclerosis, chronic renal failure, diabetic neuropathy, syndrome X, premenstrual syndrome, coronary heart disease, angina pectoris, myocardial infarction, stroke, vascular restenosis, hyperglycemia, hyperinsulinaemia, hyperlipidaemia, hypertryglyceridemia, insulin resistance, impaired glucose metabolism, conditions of impaired glucose tolerance (IGT), conditions of impaired fasting plasma glucose, obesity, diabetic retinopathy, macular degeneration, cataracts, diabetic nephropathy, glomerulosclerosis, diabetic neuropathy, erectile dysfunction, skin and connective tissue disorders, foot ulcerations and ulcerative colitis, endothelial dysfunction and impaired vascular compliance.  
   
   
       15 . The composition according to  claim 6  for the prevention, delay of progression or treatment of a of disease or disorder selected from the group consisting of hypertension, congestive heart failure, diabetes, especially type 2 diabetes mellitus, diabetic retinopathy, macular degeneration, diabetic nephropathy, glomerulosclerosis, chronic renal failure, diabetic neuropathy, syndrome X, premenstrual syndrome, coronary heart disease, angina pectoris, myocardial infarction, stroke, vascular restenosis, hyperglycemia, hyperinsulinaemia, hyperlipidaemia, hypertryglyceridemia, insulin resistance, impaired glucose metabolism, conditions of impaired glucose tolerance (IGT), conditions of impaired fasting plasma glucose, obesity, diabetic retinopathy, macular degeneration, cataracts, diabetic nephropathy, glomerulosclerosis, diabetic neuropathy, erectile dysfunction, skin and connective tissue disorders, foot ulcerations and ulcerative colitis, endothelial dysfunction and impaired vascular compliance.  
   
   
       16 . The composition according to  claim 2  for the prevention, delay of progression or treatment of a of disease or disorder selected from the group consisting of hypertension, especially ISH, congestive heart failure, endothelial dysfunction, impaired vascular compliance, IGT and type II diabetes mellitus.  
   
   
       17 . The composition according to  claim 3  for the prevention, delay of progression or treatment of a of disease or disorder selected from the group consisting of hypertension, especially ISH, congestive heart failure, endothelial dysfunction, impaired vascular compliance, IGT and type II diabetes mellitus.  
   
   
       18 . The composition according to  claim 4  for the prevention, delay of progression or treatment of a of or disorder selected from the group consisting of hypertension, especially ISH, congestive heart failure, endothelial dysfunction, impaired vascular compliance, IGT and type II diabetes mellitus.  
   
   
       19 . The composition according to  claim 5  for the prevention, delay of progression or treatment of a of or disorder selected from the group consisting of hypertension, especially ISH, congestive heart failure, endothelial dysfunction, impaired vascular compliance, IGT and type II diabetes mellitus.  
   
   
       20 . The composition according to  claim 6  for the prevention, delay of progression or treatment of a of disease or disorder selected from the group consisting of hypertension, especially ISH, congestive heart failure, endothelial dysfunction, impaired vascular compliance, IGT and type II diabetes mellitus.  
   
   
       21 . The composition according to  claim 7  for the prevention, delay of progression or treatment of a of disease or disorder selected from the group consisting of hypertension, especially ISH, congestive heart failure, endothelial dysfunction, impaired vascular compliance, IGT and type II diabetes mellitus.