Reinforced absorbable multilayered hemostatic wound dressing

Abstract

The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and fibrinogen.

1 . A multilayered wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and fibrinogen.  
   
   
       2 . The multilayered dressing of  claim 1 , where the first absorbable nonwoven fabric comprises fibers comprised of aliphatic polyester polymers or copolymers of one or more monomers selected from the group consisting of lactic acid, lactide (including L-, D-, meso and D, L mixtures), glycolic acid, glycolide, ε-caprolactone, p-dioxanone, and trimethylene carbonate.  
   
   
       3 . The multilayered dressing of  claim 2 , where the first absorbable nonwoven fabric comprises glycolide/lactide copolymer.  
   
   
       4 . The multilayered dressing of  claim 2 , where the second absorbable woven or knitted fabric comprises oxidized polysaccharides.  
   
   
       5 . The multilayered dressing of  claim 4 , where the second absorbable woven or knitted fabric comprises oxidized cellulose.  
   
   
       6 . The multilayered dressing of  claim 5 , where the second absorbable woven or knitted fabric comprises oxidized regenerated cellulose.  
   
   
       7 . The multilayered dressing of  claim 5 , where the second absorbable woven or knitted fabric is an absorbable knitted fabric comprising oxidized regenerated cellulose.  
   
   
       8 . The multilayered dressing of  claim 1 , where the first absorbable nonwoven fabric comprises glycolide/lactide copolymer, and the second absorbable woven or knitted fabric comprises oxidized regenerated cellulose.  
   
   
       9 . The multilayered dressing of  claim 8 , where the first absorbable nonwoven fabric comprises staple having a length from about 0.75 to 1.5 inches.  
   
   
       10 . The multilayered dressing of  claim 9 , where the staple is crimped.  
   
   
       11 . The multilayered dressing of  claim 8 , where the first absorbable nonwoven fabric comprises staple having a length from about 1.0 to 1.3 inches.  
   
   
       12 . The multilayered dressing of  claim 11 , where the staple is crimped.  
   
   
       13 . The multilayered dressing of  claim 8 , where the first absorbable nonwoven fabric comprises from about 70 to 95% by molar basis polyglycolide and the remainder polylactide, and the second absorbable woven or knitted fabric comprises oxidized regenerated cellulose.  
   
   
       14 . The multilayered dressing of  claim 11 , where the staple is derived from fiber of about 1 to 4 denier per filament.  
   
   
       15 . The multilayered dressing of  claim 14 , where the first absorbable nonwoven fabric has a basis weight of about 0.01 to 0.2 g/in 2 ; the second absorbable woven or knitted fabric has a basis weight of about 0.001 to 0.2 g/in 2 ; and the multilayered dressing having the thrombin and fibrinogen thereon has a basis weight of about 0.1 and 1.0 g/in 2 .  
   
   
       16 . The multilayered dressing of  claim 8 , wherein the thrombin activity on the multilayered dressing ranges from about 20 to 500 IU/cm 2 , and the fibrinogen activity on the multilayered dressing ranges from about 2 to 15 mg/cm 2 .  
   
   
       17 . The multilayered dressing comprising a first absorbable nonwoven fabric comprising glycolide/lactide copolymer staple having a length from about 0.75 to 1.5 inch, a second absorbable woven or knitted fabric comprising oxidized regenerated cellulose, thrombin and fibrinogen; wherein the glycolide/lactide copolymer comprises from about 70 to 95% by molar basis polyglycolide and the remainder polylactide, the thrombin activity on the multilayered dressing ranges from about 20 to 500 IU/cm 2 , the fibrinogen activity on the multilayered dressing ranges from about 2 to 15 mg/cm 2 , and about 50 to 75 mass percent of the dressing is capable of being absorbed after about 14 days.  
   
   
       18 . A method for treating a wound comprising the step of applying the multilayered dressing of  claim 17  to achieve hemostasis and/or seal fluid leaks.