Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer

Abstract

The present invention relates to therapeutic associations for the treatment of cancer, comprising an effective amount of a camptothecin, or a camptothecin derivative, with an effective amount of an alkylating agent such as a platin derivative, and methods of using such therapeutic associations.

1 . A therapeutic pharmaceutical combination comprising a synergistically effective amount of camptothecin, or a camptothecin derivative, in combination with an effective amount of a platin derivative for the treatment of solid tumors.  
   
   
       2 . The composition according to  claim 1 , wherein the camptothecin derivative is CPT-11.  
   
   
       3 . The composition according to  claim 1 , wherein the platin derivative is oxaliplatin.  
   
   
       4 . The composition according to  claim 1 , wherein the camptothecin derivative is CPT-11 and the platin derivative is oxaliplatin.  
   
   
       5 . A method of treating a solid tumor in a mammal with a synergistic combination of camptothecin, or a camptothecin derivative, and a platin derivative, said method comprising administering orally an effective amount of camptothecin, or a camptothecin derivative, and administering intravenously an effective amount of a platin derivative, wherein said tumor is sensitive to said combination of camptothecin, or a camptothecin derivative, and platin derivative.  
   
   
       6 . The method according to  claim 5 , wherein the camptothecin derivative is CPT-11.  
   
   
       7 . The method according to  claim 5 , wherein the platin derivative is oxaliplatin.  
   
   
       8 . The method according to  claim 5 , wherein the camptothecin derivative is CPT-11 and the platin derivative is oxaliplatin.  
   
   
       9 . The method according to  claim 5 , wherein camptothecin, or a camptothecin derivative, and the platin derivative are administered simultaneously, semi-simultaneously, separately or, spaced out over a period of time.  
   
   
       10 . The method according to  claim 6 , wherein camptothecin, or a camptothecin derivative, and the platin derivative are administered simultaneously, semi-simultaneously, separately or, spaced out over a period of time.  
   
   
       11 . The method according to  claim 7 , wherein camptothecin, or a camptothecin derivative, and the platin derivative are administered simultaneously, semi-simultaneously, separately or, spaced out over a period of time.  
   
   
       12 . The method according to  claim 8 , wherein camptothecin, or a camptothecin derivative, and the platin derivative are administered simultaneously, semi-simultaneously, separately or, spaced out over a period of time.