US2006084057A1PendingUtilityA1

Methods of diagnosing liver fibrosis

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Assignee: PROMETHEUS LABPriority: Feb 28, 2002Filed: Feb 28, 2003Published: Apr 20, 2006
Est. expiryFeb 28, 2022(expired)· nominal 20-yr term from priority
Inventors:Steven RoseEsther OhMichael J. Walsh
G01N 2333/4713Y10S436/82Y10S436/811G01N 2800/52G01N 33/5767G01N 2800/085G01N 33/6893Y10T436/143333G01N 2333/8107Y02A90/10Y10S706/924G01N 2333/8146
45
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Claims

Abstract

The present invention provides a method of diagnosing the presence or severity of liver fibrosis in an individual by detecting α2-macroglobulin (α2-MG) in sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of a metalloproteinases-1 (TIMP-1) in a sample from the individual; and diagnosing the presence or severity of liver fibrosis in the individual based on the presence or level of α-MG, HA and TIMP-1.

Claims

exact text as granted — not AI-modified
1 . A method of diagnosing the presence or severity of liver fibrosis in an individual, comprising the steps of: 
 (a) detecting α2-macroglobulin in a sample from said individual;    (b) detecting hyaluronic acid (HA) in a sample from said individual;    (c) detecting tissue inhibitor of metalloproteinases-1 (TIMP-1) in a sample from said individual; and    (d) diagnosing the presence or severity of liver fibrosis in said individual based on the presence or level of α2-MG, HA and TIMP-1.    
     
     
         2 - 74 . (canceled)

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