Composition comprising bamboo extract and the compounds isolated therefrom showing treating and preventing activity for inflammatory and blood circulation disease

Abstract

The present invention relates to a composition comprising a bamboo plant extract for the prevention and treatment of inflammatory or blood circulation disease. The extracts of bamboo plant has potent anti-inflammatory activity by inhibiting NO production and blood circulation-improving activity by inhibiting elastase activity and healing the wound of vascular endothelial cell, activating u-PA expression and inhibiting PAI-1 expression, lowering cholesterol deposit and inhibiting neointima formation, therefore it can be used as a therapeutic or health care food for treating and preventing inflammatory or blood circulation diseases.

1 . A pharmaceutical composition comprising the crude extract or non-polar solvent soluble extract of Bamboo plant as an active ingredients for the treatment and prevention of cardiovascular disease.  
   
   
       2 . A pharmaceutical composition comprising the crude extract or non-polar solvent soluble extract of Bamboo plant as an active ingredients for the treatment and prevention of blood circulation disease.  
   
   
       3 . A pharmaceutical composition comprising the crude extract or non-polar solvent soluble extract of Bamboo plant as an active ingredients for the treatment and prevention of inflammatory disease.  
   
   
       4 . The pharmaceutical composition according to any of  claims 1  to  3  wherein said crude extract is extracted with the solvent selected from the group consisting of water, lower alcohol and the mixture thereof.  
   
   
       5 . The pharmaceutical composition according to any of  claims 1  to  3  wherein said non-polar solvent soluble extract is extracted with non-polar solvent selected from the group consisting of hexane, ethyl acetate, chloroform and dichloromethane.  
   
   
       6 . The pharmaceutical composition according to any of  claims 1  to  5  wherein said bamboo is belonged to  Sasa  genus or  Phyllostachys  genus.  
   
   
       7 . The pharmaceutical composition according to  claim 6  wherein said bamboo is selected from the group consisting of  Sasa borealis  Makino,  Sasa coreana  Nakai,  Sasa japonica  Makino,  Sasa borealis  var.  gracilis  and  Sasa palmata  Nakai.  
   
   
       8 . The pharmaceutical composition according to  claim 6  wherein said bamboo plant is selected from the group consisting of  Phyllostachysbambusoides  SIEB. Et Zucc,  Phyllostachys nigra  MUNRO,  Phyllostachys nigra  MUNRO var.  henonis  STAPF and  Phyllostachyspubescens  MAZEL ex H. de LEH.  
   
   
       9 . A pharmaceutical composition comprising tricin or p-coumaric acid isolated from bamboo plant and the pharmaceutically acceptable salt thereof as an active ingredient for the treatment and prevention of cardiovascular disease.  
   
   
       10 . A pharmaceutical composition comprising tricin or p-coumaric acid isolated from bamboo plant or the pharmaceutically acceptable salt thereof as an active ingredient for the treatment and prevention of blood circulation disease.  
   
   
       11 . A pharmaceutical composition comprising tricin or p-coumaric acid isolated from bamboo plant or the pharmaceutically acceptable salt thereof as an active ingredient for the treatment and prevention of inflammation.  
   
   
       12 . The pharmaceutical composition according to any of  claims 9  to  11  wherein said the bamboo plant is at least one selected from the group consisting of  Phyllostachys bambusoides  SIEB. Et Zucc,  Phyllostachys nigra  MUNRO,  Phyllostachys nigra  MUNRO var.  henonis  STAPF,  Phyllostachys pubescens  MAZEL ex H. de LEH or  Sasa borealis  Makino,  Sasa coreana  Nakai,  Sasa japonica  Makino,  Sasaborealis  var.  gracilis, Sasa palmata  Nakai,  Setaria viridis  BEAUV and  Oryza sativa  L.  
   
   
       13 . The pharmaceutical composition according to  claim 12  wherein said bamboo plant is  Phyllostachys nigra  MUNRO var.  henonis  STAPF. or  Sasa borealis  Makino.  
   
   
       14 . The pharmaceutical composition according to  claim 1  or  9  wherein said cardiovascular disease comprises various cardiovascular diseases such as hypertension, heart disease, brain stroke, peripheral blood disease, thrombosis, stenosis, hyperlipemia, arteriosclerosis, or cardiac infarction.  
   
   
       15 . The pharmaceutical composition according to  claim 3  or  11  wherein said inflammatory disease comprises arthritis, atheriosclerosis, gastritis, colitis, nephritis, hepatitis, cancer or degenerative disease.  
   
   
       16 . A health care food comprising the crude extract or non-polar solvent soluble extract of Bamboo plant as set forth in  claim 1  or tricin or p-coumaric acid as set forth in  claim 9 , together with a sitologically acceptable additive for the prevention and treatment of cardiovascular disease.  
   
   
       17 . A health care food comprising the crude extract or non-polar solvent soluble extract of Bamboo plant as set forth in  claim 2  or tricin or p-coumaric acid as set forth in  claim 10 , together with a sitologically acceptable additive for the prevention and treatment of blood circulation disease.  
   
   
       18 . A health care food comprising the crude extract or non-polar solvent soluble extract of Bamboo plant as set forth in  claim 3  or tricin or p-coumaric acid as set forth in  claim 11 , together with a sitologically acceptable additive for the prevention and treatment of inflammation.