Substituted 2-phenyl benzofurans as estrogenic agents

Abstract

This invention provides estrogen receptor modulators of formula 1, having the structure wherein R, R′, A, A′, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.

1 - 15 . (canceled)  
   
   
       16 . A method of treating or inhibiting arthritis in a mammal in need thereof, which comprises providing to said mammal an effective amount of a compound of formula I, having the structure  
     
       
         
         
             
             
         
       
     
     wherein 
 P and P′ are each, independently, hydrogen, alkyl of 1-6 carbon atoms, or acyl of 2-7 carbon atoms;  
 X is hydrogen or halogen;  
 R is hydrogen, alkyl of 1-6 carbon atoms, halogen, —CN, or —CHO;  
 R′ is alkoxy of 1-6 carbon atoms, or cyanoalkyl having 1-6 carbon atoms in the alkyl moiety;  
 or a pharmaceutically acceptable salt thereof.  
 
   
   
       17 . The method according to  claim 16 , wherein the arthritis is rheumatoid arthritis, osteoarthritis or spondyloarthropathies.  
   
   
       18 . A method of treating or inhibiting joint swelling or erosion; or treating or inhibiting joint damage secondary to arthroscopic or surgical procedures in a mammal in need thereof, which comprises providing to said mammal an effective amount of a compound of formula I, having the structure  
     
       
         
         
             
             
         
       
     
     wherein 
 P and P′ are each, independently, hydrogen, alkyl of 1-6 carbon atoms, or acyl of 2-7 carbon atoms;  
 X is hydrogen or halogen;  
 R is hydrogen, alkyl of 1-6 carbon atoms, halogen, —CN, or —CHO;  
 R′ is alkoxy of 1-6 carbon atoms, or cyanoalkyl having 1-6 carbon atoms in the alkyl moiety;  
 or a pharmaceutically acceptable salt thereof.  
 
   
   
       19 - 22 . (canceled)