Pharmaceutical compositions and methods for managing skin conditions

Abstract

This application relates to a stable pharmaceutical composition and methods for the cleaning of skin to facilitate the prevention, treatment, and management of skin conditions, such as seborrheic dermatitis, psoriasis, folliculitis, rosacea, perioral dermatitis, acne, impetigo and other inflammatory skin conditions, and the like, including a sufficient amount of an acidic component of a hydroxyacid or tannic acid, or a pharmaceutically acceptable salt thereof, to exfoliate a portion of the skin, a sufficient amount of stabilized hydrogen peroxide to facilitate cleansing of the skin without substantial irritation thereof, and an antimicrobial agent including at least one of an antibacterial agent, antimicrobial agent, antiviral agent, anthelmintic, or a combination thereof, in an amount sufficient to inhibit or reduce microorganisms on the skin.

1 . A skin cleansing pharmaceutical composition comprising: 
 an acidic component comprising a hydroxy acid or tannic acid, or a pharmaceutically acceptable salt thereof, present in an amount greater than about 4 weight percent sufficient to exfoliate at least a portion of the skin;    hydrogen peroxide in an amount sufficient to cleanse the skin without substantial irritation thereof; and    an anthelmintic in an amount sufficient to at least inhibit microorganisms on the skin.    
   
   
       2 . The pharmaceutical composition of  claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier or excipient.  
   
   
       3 . The pharmaceutical composition of  claim 1 , wherein the acidic component comprises glycolic acid, lactic acid, citric acid, salicylic acid, or tannic acid.  
   
   
       4 . The pharmaceutical composition of  claim 1 , further comprising an amount of amphoteric surfactant and an amount of citric acid sufficient to inhibit hydrogen peroxide decomposition for at least three months.  
   
   
       5 . The pharmaceutical composition of  claim 4 , wherein the amount of amphoteric surfactant and citric acid is sufficient to inhibit hydrogen peroxide decomposition at 40° C. for at least three months.  
   
   
       6 . The pharmaceutical composition of  claim 1 , wherein the acidic component is present in an amount from about 4 to 12 weight percent, the hydrogen peroxide is present in an amount from about 0.01 to 6 weight percent, and the anthelmintic is present in an amount from about 0.01 to 1.5 weight percent, of the composition.  
   
   
       7 . The pharmaceutical composition of  claim 1 , further comprising at least one of a surfactant, a stabilizer, a preservative, a moisturizer, anti-inflammatory agent, anti-oxidant, or a coloring agent, which together may be present in an amount from about 10.1 to 99.1 weight percent of the composition.  
   
   
       8 . A gel, paste, cream, lotion, emulsion, or ointment comprising the pharmaceutical composition of  claim 1 .  
   
   
       9 . A method of managing a skin condition comprising administering to a patient a therapeutically effective amount of the pharmaceutical composition of  claim 1 .  
   
   
       10 . The method of  claim 9 , wherein the skin condition is selected from the group consisting of seborrheic dermatitis, psoriasis, folliculitis, rosacea, perioral dermatitis, acne, and impetigo.  
   
   
       11 . The method of  claim 10 , wherein the skin condition is rosacea.  
   
   
       12 . The method of  claim 9 , wherein the skin condition is a tricomona infection.  
   
   
       13 . The method of  claim 9 , wherein the pharmaceutical composition is administered topically.  
   
   
       14 . A method of managing a skin condition comprising administering to a patient a therapeutically effective amount of the pharmaceutical composition of  claim 8 .  
   
   
       15 . A method of managing a skin condition comprising administering to a patient a therapeutically effective amount of the pharmaceutical composition of  claim 7 .  
   
   
       16 . A method of managing a skin condition comprising administering to a patient a therapeutically effective amount of the pharmaceutical composition of  claim 3.