IGF-1 receptor interacting proteins

Abstract

The invention comprises a nucleic acid molecule with the sequence SEQ ID NO:5 and the complementary sequence, and its use in diagnosis and therapy. This nucleic acid molecule (IIP-10) is a gene which encodes an IGF-1 receptor binding polypeptide.

1 . A method for the production of a therapeutic agent for the treatment of carcinomas in a patient comprising combining a pharmaceutically acceptable carrier with a therapeutically effective amount of a compound which modulates the interaction between IGF-1R and IIP-10 in a cellular assay, whereby in said cellular assay tumor cells or cells transfected with expression constructs of IGF-1R and of said IIP are treated with said compound, and complex formation between IGF-1R and said respective IIP is analyzed, and the extent of said complex formation in the case of inhibition does not exceed 50% when referenced against100% for complex formation without said compound in said same cellular assay.