US2006021623A1PendingUtilityA1

Methods and compositions for treating ocular glaucoma

50
Individually held — no corporate assignee on recordPriority: Jul 30, 2004Filed: Jul 27, 2005Published: Feb 2, 2006
Est. expiryJul 30, 2024(expired)· nominal 20-yr term from priority
Inventors:Joan W. MillerAkihisa MatsubaraDeeba HusainEvangelos S. Gragoudas
A61K 41/0061A61K 41/0057A61F 9/00781A61N 5/062A61F 9/0079A61F 9/008A61F 2009/00868A61K 41/0076A61N 2005/0662A61F 2009/00891A61K 41/0071A61P 27/00A61N 5/067
50
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

The invention provides a photodynamic therapy-based method for treating ocular glaucoma. A photosensitizer, for example, a benzoporphyrin derivative photosensitizer, is administered to a mammal either having or at risk of developing ocular glaucoma. The photosensitizer, when present in the ciliary body, is activated by light, for example, light from a laser. The treatment results in a reduction of intraocular pressure within the treated eye, which can persist for a prolonged period of time.

Claims

exact text as granted — not AI-modified
1 . A method of reducing the intraocular pressure in a mammalian eye having a ciliary body, the method comprising the steps of: 
 (a) administering to a mammal, an amount of photosensitizer sufficient to accumulate in the ciliary body; and    (b) irradiating a region within the ciliary body with light so as to activate the photosensitizer, wherein the activated photosensitizer causes a decrease in the intraocular pressure in the eye relative to the intraocular pressure in the eye prior to irradiation for a prolonged period of time.    
     
     
         2 . The method of  claim 1 , wherein the photosensitizer is a benzoporphyrin derivative.  
     
     
         3 . The method of  claim 2 , wherein the photosensitizer is benzoporphyrin derivative mono-acid.  
     
     
         4 . The method of  claim 1 , wherein the amount of photosensitizer is about 1 mg/kg.  
     
     
         5 . The method of  claim 1 , wherein the light comprises a wavelength of about 689 nm.  
     
     
         6 . The method of  claim 1 , wherein the irradiating step comprises a fluence of about 100 Joules/cm 2 .  
     
     
         7 . The method of  claim 1 , wherein the irradiating step comprises an irradiance of about 1800 mW/cm 2 .  
     
     
         8 . The method of  claim 1 , wherein the irradiating step comprises irradiating 180 degrees of the ciliary body.  
     
     
         9 . The method of  claim 1 , wherein the irradiation reduces the intraocular pressure in the eye by at least 20% of the intraocular pressure in the eye prior to irradiation.  
     
     
         10 . The method of  claim 1 , wherein the irradiation reduces the intraocular pressure for at least 4 weeks.  
     
     
         11 . A method of treating glaucoma in a mammalian eye having a ciliary body, the method comprising the steps of: 
 (a) administering to a mammal, an amount of photosensitizer sufficient to accumulate in the ciliary body; and    (b) irradiating a region within the ciliary body with light to activate the photosensitizer, so as to reduce the intraocular pressure in the eye relative to the intraocular pressure in the eye prior to irradiation for a prolonged period of time.    
     
     
         12 . The method of  claim 11 , wherein the photosensitizer is a benzoporphyrin derivative.  
     
     
         13 . The method of  claim 12 , wherein the photosensitizer is benzoporphyrin derivative mono-acid.  
     
     
         14 . The method of  claim 11 , wherein the amount of photosensitizer is about 1 mg/kg.  
     
     
         15 . The method of  claim 11 , wherein the light comprises a wavelength of about 689 nm.  
     
     
         16 . The method of  claim 11 , wherein the irradiating step comprises a fluence of about 100 Joules/cm 2 .  
     
     
         17 . The method of  claim 11 , wherein the irradiating step comprises an irradiance of about 1800 mW/cm 2 .  
     
     
         18 . The method of  claim 11 , wherein the irradiating step comprises irradiating 180 degrees of the ciliary body.  
     
     
         19 . The method of  claim 11 , wherein the irradiation reduces the intraocular pressure in the eye by at least 20% of the intraocular pressure in the eye prior to irradiation.  
     
     
         20 . The method of  claim 11 , wherein the irradiation reduces the intraocular pressure for at least 4 weeks.  
     
     
         21 . A method of treating glaucoma in a mammalian eye having a ciliary body, the method comprising the steps of: 
 (a) administering to a mammal, an amount of a benzoporphyrin derivative photosensitizer sufficient to accumulate in the ciliary body; and    (b) irradiating a region within the ciliary body with light to activate the photosensitizer,    wherein the activated photosensitizer causes a reduction in the intraocular pressure in the eye relative to the intraocular pressure in the eye prior to irradiation.    
     
     
         22 . The method of  claim 21 , wherein the photosensitizer is benzoporphyrin derivative mono-acid.  
     
     
         23 . The method of  claim 21 , wherein the amount of photosensitizer is about 1 mg/kg.  
     
     
         24 . The method of  claim 21 , wherein the light comprises a wavelength of about 689 nm.  
     
     
         25 . The method of  claim 21 , wherein the irradiating step comprises a fluence of about 100 Joules/cm 2 .  
     
     
         26 . The method of  claim 21 , wherein the irradiating step comprises an irradiance of about 1800 mW/cm 2 .  
     
     
         27 . The method of  claim 21 , wherein the irradiating step comprises irradiating 180 degrees of the ciliary body.  
     
     
         28 . The method of  claim 21 , wherein the irradiation reduces the intraocular pressure in the eye by at least 20% of the intraocular pressure in the eye prior to irradiation.  
     
     
         29 . The method of  claim 21 , wherein the irradiation reduces the intraocular pressure for a prolonged period of time.  
     
     
         30 . The method of  claim 21 , wherein the irradiation reduces the intraocular pressure for at least 4 weeks.  
     
     
         31 . A method of reducing intraocular pressure for a prolonged period of time in an eye having a ciliary body, the method comprising the steps of: 
 (a) administering to a mammal an amount of a benzoporphyrin derivative photosensitizer sufficient to accumulate in the ciliary body; and    (b) irradiating a region of the ciliary body with light, wherein the light activates the photosensitizer and wherein the activated photosensitizer causes a reduction in the intraocular pressure in the eye relative to the intraocular pressure in the eye prior to irradiation for a prolonged period of time.    
     
     
         32 . A method of preserving retinal ganglion cell viability in a mammalian eye having a ciliary body and at risk of developing or having glaucoma, the method comprising the steps of: 
 (a) administering to a mammal, an amount of photosensitizer sufficient to accumulate in the ciliary body; and    (b) irradiating a region within the ciliary body with light so as to activate the photosensitizer, such that retinal ganglion cell viability is preserved.    
     
     
         33 . The method of  claim 32 , wherein the photosensitizer is a benzoporphyrin derivative.  
     
     
         34 . The method of  claim 32 , wherein the photosensitizer is benzoporphyrin derivative mono-acid.  
     
     
         35 . The method of  claim 32 , wherein the amount of photosensitizer is about 1 mg/kg.  
     
     
         36 . The method of  claim 32 , wherein the light comprises a wavelength of about 689 nm.  
     
     
         37 . The method of  claim 32 , wherein the irradiating step comprises a fluence of about 100 Joules/cm 2 .  
     
     
         38 . The method of  claim 32 , wherein the irradiating step comprises an irradiance of about 1800 mW/cm 2 .  
     
     
         39 . The method of  claim 32 , wherein the irradiating step comprises irradiating 180 degrees of the ciliary body.  
     
     
         40 . The method of  claim 32 , wherein the irradiation reduces the intraocular pressure in the eye by at least 20% of the intraocular pressure in the eye prior to irradiation.  
     
     
         41 . The method of  claim 32 , wherein the irradiation reduces the intraocular pressure for at least 4 weeks.  
     
     
         42 . The method of  claim 32 , wherein the irradiation reduces the intraocular pressure for a prolonged period of time.

Join the waitlist — get patent alerts

Track US2006021623A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.