US2006019382A1PendingUtilityA1

Transcriptionally-activated AAV inverted terminal repeats (ITRs) for use with recombinant AAV vectors

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Individually held — no corporate assignee on recordPriority: Oct 21, 1997Filed: Jun 3, 2005Published: Jan 26, 2006
Est. expiryOct 21, 2017(expired)· nominal 20-yr term from priority
Inventors:Andrew Lawrence Feldhaus
C12N 15/86C12N 2750/14143C07K 14/4712A61K 48/00C12N 2830/00
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Claims

Abstract

This invention provides transcriptionally-activated AAV ITRs (inverted terminal repeats) which are small and transcriptionally active and uses thereof to optimize the expression of relatively large transgenes packaged in recombinant AAV vectors.

Claims

exact text as granted — not AI-modified
1 . A polynucleotide comprising a transcriptionally-activated Adeno-associated virus (AAV) inverted terminal repeat (ITR), wherein the transcriptionally-activated ITR is less than about 400 bp in length and comprises a heterologous transcriptionally active element, and wherein the transcriptionally-activated ITR exhibits at least about a two-fold increase in transcriptional activity relative to a wild-type ITR under conditions permissive for transcription.  
     
     
         2 - 35 . (canceled)

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