Diagnosis and treatment of PTP related disorders

Abstract

The present invention relates to PTP05 polypeptides and PTP10 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for PTP05 and/or PTP10 related diseases or conditions characterized by an abnormal interaction between a PTP05 polypeptide and a PTP05 binding partner and/or a PTP10 polypeptide and a PTP10 binding partner.

1 - 15 . (canceled)  
     
     
         16 . A method for identifying a substance capable of modulating PTP05 or PTP10 activity in a cell comprising the steps of: 
 (a) expressing a PTP05 or a PTP10 polypeptide in a cell,    (b) adding a test substance to said cells, and    (c) monitoring a change in cell phenotype, cell proliferation, cell differentiation, PTP05 or PTP10 catalytic activity, or the interaction between a PTP05 or a PTP10 polypeptide and a natural binding partner.    
     
     
         17 . A method of preventing or treating an abnormal condition by administering to a patient in need of such treatment a compound that modulates the function of a PTP05 or a PTP10 polypeptide.  
     
     
         18 . The method of  claim 17 , wherein said abnormal condition involves an abnormality in PTO05 or PTP10 signal transduction pathway.  
     
     
         19 . The method of  claim 18 , wherein said abnormal condition is cancer.  
     
     
         20 . The method of  claim 17 , wherein said compound modulates the function of a PTP05 or a PTP10 polypeptide in vitro.  
     
     
         21 - 22 . (canceled)