Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers

Abstract

A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1D7 provides a diagnostic and/or therapeutic target for cancers. The 158P1D7 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.

1 . An isolated and purified polypeptide comprising SEQ ID NO: 657.  
     
     
         2 . The isolated and purified polypeptide of  claim 1 , wherein the polypeptide is encoded by a polynucleotide.  
     
     
         3 . The isolated and purified polypeptide of  claim 2 , wherein the polynucleotide comprises SEQ ID NO: 656.  
     
     
         4 . An expression vector comprising a nucleotide sequence encoding a polypeptide comprising SEQ ID NO: 657.  
     
     
         5 . The expression vector of  claim 4 , wherein the nucleotide sequence comprises SEQ ID NO: 656.