Compositions containing topical active agents and pentylene glycol

Abstract

Disclosed are cosmetic and dermatological compositions containing hydrocortisone or a derivative thereof, a glycol and a thickening or gelling agent, and methods of making and using them.

1 . A cosmetic composition for application to skin, comprising: 
 hydrocortisone or a derivative thereof;    at least one glycol; and    a gelling agent comprising a polymeric constituent, an aqueous phase, at least one emulsifier, wherein said polymeric constituent is selected from the group consisting of: 
 a) a polyelectrolyte that is a homopolymer based on a monomer having a partially or completely salified strong acid functional group, or a copolymer based on at least one monomer having a partially or completely salified strong acid functional group copolymerized with acrylamide;  
 b) an anionic polyelectrolyte based on at least one monomer possessing a strongly acidic function, copolymerized either with at least one monomer possessing a weakly acidic function or with at least one neutral monomer;  
 c) polyacrylamide or a copolymer containing units derived from (a) acrylamide (b) AMPS, and (c) a polyfunctional monomer in an amount of from 0.12 to 2 milliequivalents inclusive per mole of total monomer units, at least some of the AMPS units being in a neutral salt form;  
 d) an anionic polyelectrolyte based on partially neutralized acrylic acid; and  
 e) at least one anionic polyelectrolyte chosen from: branched or crosslinked homopolymers of a monomer possessing a partially or completely salified strong acid functional group, branched or crosslinked homopolymers of a monomer possessing a partially or completely salified weak acid functional group, branched or crosslinked copolymers of monomers possessing a partially or completely salified strong acid functional group, branched or crosslinked copolymers of monomers possessing a partially or completely salified weak acid functional group, branched or crosslinked copolymers of monomers possessing a partially or completely salified strong acid functional group and either of at least one monomer possessing a partially or completely salified weak acid functional group and/or of at least one neutral monomer, and branched or crosslinked copolymers of monomers possessing a partially or completely salified weak acid functional group and at least one neutral monomer;  
 wherein said gelling agent optionally comprises an oil phase comprising a hydrocarbon.  
   
     
     
         2 . The composition of  claim 1 , wherein said polyelectrolyte of a) comprises a copolymer containing in molar proportions, from about 30% to about 50% of 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulphonic acid (AMPS™), partially or completely salified in the form of the sodium salt or of the ammonium salt, and from about 50% to about 70% of acrylamide.  
     
     
         3 . The composition of  claim 2 , wherein said at least one emulsifying agent comprises a polyethoxylated sorbitan ester.  
     
     
         4 . The composition of  claim 2 , wherein said gelling agent comprises an oil phase comprising isohexadecane.  
     
     
         5 . The composition of  claim 2 , wherein AMPS is partially or completely salified in the form of the sodium salt, said at least one emulsifying agent comprises Polysorbate 80 and wherein said gelling comprises an oil phase comprising isohexadecane.  
     
     
         6 . The composition of  claim 1 , wherein said polyelectrolyte of a) comprises a homopolymer of 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulphonic acid (AMPS™) partially or completely salified in the form of the sodium salt or of the ammonium salt.  
     
     
         7 . The composition of  claim 6 , wherein said at least one emulsifying agent comprises a polyethoxylated sorbitan ester.  
     
     
         8 . The composition of  claim 6 , wherein said gelling agent comprises an oil phase comprising isohexadecane.  
     
     
         9 . The composition of  claim 6 , wherein AMPS is partially or completely salified in the form of the sodium salt, said at least one emulsifying agent comprises Polysorbate 80 and wherein said gelling agent comprises an oil phase comprising isohexadecane.  
     
     
         10 . The composition of  claim 1 , wherein said polyelectrolyte of b) comprises AMPS, which is partially or totally salified in the form of the sodium or ammonium salt, copolymerized with acrylic acid, partially salified in the form of the sodium salt or ammonium salt.  
     
     
         11 . The composition of  claim 10 , wherein said at least one emulsifying agent comprises a polyethoxylated sorbitan ester.  
     
     
         12 . The composition of  claim 10 , wherein said gelling agent comprises an oil phase comprising isohexadecane.  
     
     
         13 . The composition of  claim 10 , wherein AMPS is partially or completely salified in the form of the sodium salt, acrylic acid is partially salified in the form of the sodium salt said at least one emulsifying agent comprises Polysorbate 80 and wherein said gelling agent comprises an oil phase comprising isohexadecane.  
     
     
         14 . The composition of  claim 1 , wherein c) comprises polyacrylamide.  
     
     
         15 . The composition of  claim 14 , wherein said at least one emulsifier comprises a polyethoxylated lauryl alcohol.  
     
     
         16 . The composition of  claim 15 , wherein said gelling agent comprises an oil phase comprising isoparaffin.  
     
     
         17 . The composition of  claim 1 , comprising said anionic polyelectrolyte of d).  
     
     
         18 . The composition of  claim 17 , wherein said at least one emulsifier comprises a polyethoxylated sorbitan ester.  
     
     
         19 . The composition of  claim 18 , wherein said hydrocarbon comprises polyisobutene.  
     
     
         20 . The composition of  claim 1 , wherein e) comprises hydroxyethylacrylate/sodium acryloyldimethyl taurate copolyer.  
     
     
         21 . The composition of  claim 1 , comprising hydrocortisone.  
     
     
         22 . The composition of  claim 1 , wherein said at least one glycol comprises pentylene glycol.  
     
     
         23 . The composition of  claim 22 , wherein pentylene glycol is present in an amount of at least 5% by weight based on total weight of said composition.  
     
     
         24 . The composition of  claim 22 , wherein pentylene glycol is present in an amount of at least 7% by weight based on total weight of said composition.  
     
     
         25 . The composition of  claim 22 , further comprising at least one other glycol.  
     
     
         26 . The composition of  claim 25 , wherein the amount of said glycols is at least about 15% based on total weight of said composition.  
     
     
         27 . The composition of  claim 1 , comprising hydrocortisone and pentylene glycol.  
     
     
         28 . A method of increasing stability of hydrocortisone or a derivative thereof, comprising: 
 combining hydrocortisone or a derivative thereof;    at least one glycol; and    a gelling agent comprising a polymeric constituent, an aqueous phase, and an emulsifier; thereby preparing a cosmetic composition for application to skin, wherein the polymeric constituent is selected from the group consisting of: 
 a) a polyelectrolyte that is a homopolymer based on a monomer having a partially or completely salified strong acid functional group, or a copolymer based on at least one monomer having a partially or completely salified strong acid functional group copolymerized with acrylamide;  
 b) an anionic polyelectrolyte based on at least one monomer possessing a strongly acidic function, copolymerized either with at least one monomer possessing a weakly acidic function or with at least one neutral monomer;  
 c) polyacrylamide or a copolymer containing units derived from (a) acrylamide (b) AMPS, and (c) a polyfunctional monomer in an amount of from 0.12 to 2 milliequivalents inclusive per mole of total monomer units, at least some of the AMPS units being in a neutral salt form;  
 d) an anionic polyelectrolyte based on partially neutralized acrylic acid; and  
 e) at least one anionic polyelectrolyte chosen from: branched or crosslinked homopolymers of a monomer possessing a partially or completely salified strong acid functional group, branched or crosslinked homopolymers of a monomer possessing a partially or completely salified weak acid functional group, branched or crosslinked copolymers of monomers possessing a partially or completely salified strong acid functional group, branched or crosslinked copolymers of monomers possessing a partially or completely salified weak acid functional group, branched or crosslinked copolymers of monomers possessing a partially or completely salified strong acid functional group and either of at least one monomer possessing a partially or completely salified weak acid functional group and/or of at least one neutral monomer, and branched or crosslinked copolymers of monomers possessing a partially or completely salified weak acid functional group and at least one neutral monomer; and  
 wherein said gelling agent optionally comprises an oil phase comprising a hydrocarbon.  
   
     
     
         29 . A method of treating skin, comprising applying to skin a cosmetic composition comprising: 
 hydrocortisone or a derivative thereof;    at least one glycol; and    a gelling agent comprising a polymeric constituent, an aqueous phase, and an emulsifier, wherein said polymeric constituent is selected from the group consisting of: 
 a) a polyelectrolyte that is a homopolymer based on a monomer having a partially or completely salified strong acid functional group, or a copolymer based on at least one monomer having a partially or completely salified strong acid functional group copolymerized with acrylamide;  
 b) an anionic polyelectrolyte based on at least one monomer possessing a strongly acidic function, copolymerized either with at least one monomer possessing a weakly acidic function or with at least one neutral monomer;  
 c) polyacrylamide or a copolymer containing units derived from (a) acrylamide (b) AMPS, and (c) a polyfunctional monomer in an amount of from 0.12 to 2 milliequivalents inclusive per mole of total monomer units, at least some of the AMPS units being in a neutral salt form;  
 d) an anionic polyelectrolyte based on partially neutralized acrylic acid; and  
 e) at least one anionic polyelectrolyte chosen from: branched or crosslinked homopolymers of a monomer possessing a partially or completely salified strong acid functional group, branched or crosslinked homopolymers of a monomer possessing a partially or completely salified weak acid functional group, branched or crosslinked copolymers of monomers possessing a partially or completely salified strong acid functional group, branched or crosslinked copolymers of monomers possessing a partially or completely salified weak acid functional group, branched or crosslinked copolymers of monomers possessing a partially or completely salified strong acid functional group and either of at least one monomer possessing a partially or completely salified weak acid functional group and/or of at least one neutral monomer, and branched or crosslinked copolymers of monomers possessing a partially or completely salified weak acid functional group and at least one neutral monomer; and  
 wherein said gelling agent optionally comprises an oil phase comprising a hydrocarbon.