US2006008852A1PendingUtilityA1

Marine actinomycete taxon for drug and fermentation product discovery

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Assignee: UNIV CALIFORNIAPriority: Nov 16, 2000Filed: Sep 15, 2005Published: Jan 12, 2006
Est. expiryNov 16, 2020(expired)· nominal 20-yr term from priority
Inventors:William FenicalPaul JensenTracy Mincer
G01N 2333/36C12N 1/10C12Q 1/18A61P 35/00C12P 17/188C12R 2001/01C12N 1/205
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Claims

Abstract

The invention is the discovery of an actinomycete genus, given the name Salinospora gen. nov., that displays an obligate requirement of seawater (Na + ) for growth and unique 16S rRNA signature nucleotides. The invention is also the use of the genus for the production and discovery of active biomolecules such as pharmaceutical agents, agrichemicals, immunomodifiers, enzymes and enzyme inhibitors.

Claims

exact text as granted — not AI-modified
1 - 12 . (canceled)  
     
     
         13 . A compound having the following structure:  
       
         
           
           
               
               
           
         
       
       wherein the stereodescriptors depict relative stereochemistry.  
     
     
         14 . A salinosporamide A compound isolatable from an actinomycete.  
     
     
         15 . The salinosporamide compound of  claim 14 , wherein the actinomycete has an obligate requirement for sodium growth, wherein the marine actinomycete comprises 16S rRNA signature nucleotides, adenosine at position 207, cytosine at position 366, uracil at position 467 uracil at position 468, and a guanine at position 1456.  
     
     
         16 . The salinosporamide A compound of  claim 14 , wherein the actinomycete is selected from actinomycete strain CNH898, actinomycete strain CNB440, and actinomycete strain CNB536.  
     
     
         17 . A salinosporamide A compound isolated from an actinomycete.  
     
     
         18 . The salinosporamide compound of  claim 17 , wherein the actinomycete has an obligate requirement for sodium growth, wherein the marine actinomycete comprises 16S rRNA signature nucleotides, adenosine at position 207, cytosine at position 366, uracil at position 467 uracil at position 468, and a guanine at position 1456.  
     
     
         19 . The salinosporamide A compound of  claim 17 , wherein the actinomycete is selected from actinomycete strain CNH898, actinomycete strain CNB440, and actinomycete strain CNB536.  
     
     
         20 . 4-chloroethyl-5-methyl-1-((cyclohex-2-enyl)(hydroxy)methyl)-6-oxa-2-azabicyclo(3.2.0)heptane-3,7-dione.  
     
     
         21 . A 4-chloroethyl-5-methyl-1-((cyclohex-2-enyl)(hydroxy)methyl)-6-oxa-2-azabicyclo(3.2.0)heptane-3,7-dione isolated from an actinomycete having an obligate requirement for sodium growth, wherein the marine actinomycete comprises 16S rRNA signature nucleotides, adenosine at position 207, cytosine at position 366, uracil at position 467 uracil at position 468, and a guanine at position 1456.  
     
     
         22 . A 4-chloroethyl-5-methyl-1-((cyclohex-2-enyl)(hydroxy)methyl)-6-oxa-2-azabicyclo(3.2.0)heptane-3,7-dione isolatable from an actinomycete having an obligate requirement for sodium growth, wherein the marine actinomycete comprises 16S rRNA signature nucleotides, adenosine at position 207, cytosine at position 366, uracil at position 467 uracil at position 468, and a guanine at position 1456.  
     
     
         23 . A 4-chloroethyl-5-methyl-1-((cyclohex-2-enyl)(hydroxy)methyl)-6-oxa-2-azabicyclo(3.2.0)heptane-3,7-dione obtainable by the process comprising: 
 (a) growing a marine actinomycete; and    (b) extracting the 4-chloroethyl-5-methyl-1-((cyclohex-2-enyl)(hydroxy)methyl)-6-oxa-2-azabicyclo(3.2.0)heptane-3,7-dione from the marine actinomycete.    
     
     
         24 . The 4-chloroethyl-5-methyl-1-((cyclohex-2-enyl)(hydroxy)methyl)-6-oxa-2-azabicyclo(3.2.0)heptane-3,7-dione of  claim 21 , wherein marine actinomycete is selected from actinomycete strain CNH898, actinomycete strain CNB440, and actinomycete strain CNB536.  
     
     
         25 . A salinosporamide A compound obtainable by the process comprising: 
 (a) growing a marine actinomycete; and    (b) extracting the salinosporamide A compound from the marine actinomycete.    
     
     
         26 . The salinosporamide A compound of  claim 23 , wherein marine actinomycete is selected from actinomycete strain CNH898, actinomycete strain CNB440, and actinomycete strain CNB536.  
     
     
         27 . A compound having the following structure:

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