Prostate cancer diagnosis and outcome prediction by expression analysis

Abstract

Methods identifying prostate cancer, methods for prognosing and diagnosing prostate cancer, methods for identifying a compound that modulates prostate cancer development, methods for determining the efficacy of a prostate cancer therapy, and oligonucleotide microarrays containing probes for genes involved in prostate cancer development are described.

1 . A method of identifying prostate cancer comprising: determining a gene expression profile from a gene expression product of at least one prostate cancer identification informative gene in a sample obtained from prostate tissue, wherein increased or decreased expression of said gene expression product in said sample relative to a control is indicative of prostate cancer.  
     
     
         2 . The method of  claim 1 , wherein the gene expression product is RNA.  
     
     
         3 . The method of  claim 2 , wherein the gene expression profile is determined utilizing specific hybridization probes.  
     
     
         4 . The method of  claim 2 , wherein the gene expression profile is determined utilizing oligonucleotide microarrays.  
     
     
         5 . The method of  claim 1 , wherein the gene expression product is a peptide.  
     
     
         6 . The method of  claim 5 , wherein the gene expression profile is determined utilizing antibodies.  
     
     
         7 . A method of identifying prostate cancer comprising: determining a gene expression profile from the gene expression products from at least two prostate cancer identification informative genes in a sample obtained from prostate tissue, wherein increased or decreased expression of each said gene expression product in said sample relative to a control is indicative of prostate cancer.  
     
     
         8 . The method of  claim 7 , wherein said method comprises determining a gene expression profile from the gene expression products from at least four prostate cancer identification informative genes.  
     
     
         9 . The method of  claim 7 , wherein said method comprises determining a gene expression profile from the gene expression products from at least ten prostate cancer identification informative genes.  
     
     
         10 . The method of  claim 7 , wherein the gene expression product is RNA.  
     
     
         11 . The method of  claim 10 , wherein the gene expression profile is determined utilizing specific hybridization probes.  
     
     
         12 . The method of  claim 10 , wherein the gene expression profile is determined utilizing oligonucleotide microarrays.  
     
     
         13 . The method of  claim 7 , wherein the gene expression product is a peptide.  
     
     
         14 . The method of  claim 13 , wherein the gene expression profile is determined utilizing antibodies.  
     
     
         15 . The method of  claim 1 , wherein increased expression of said gene expression product in said sample relative to a control is indicative of prostate cancer.  
     
     
         16 . The method of  claim 1 , wherein decreased expression of said gene expression product in said sample relative to a control is indicative of prostate cancer  
     
     
         17 . The method of  claim 7 , wherein increased expression of each said gene expression product in said sample relative to a control is indicative of prostate cancer.  
     
     
         18 . The method of  claim 7 , wherein increased expression of each said gene expression product in said sample relative to a control is indicative of prostate cancer.