Ethylenediamine derivatives

Abstract

The invention relates a compound represented by the formula (1): Q 1 -Q 2 -C(═O)—N(R 1 )-Q 3 -N(R 2 )-T 1 -Q 4   (1) wherein R 1 and R 2 represent H or the like; Q 1 represents an aromatic ring, heterocyclic ring or the like; Q 2 represents a single bond, aromatic ring, heterocyclic ring or the like; Q 3 represents a group or the like, Q 4 represents an aromatic ring, heterocyclic ring or the like; and T 1 represents —CO— or —SO 2 —, and a medicine which comprises the compound and is useful for thrombosis and embolism.

1 - 21 . (canceled)  
   
   
       22 . A compound represented by the following general formula (4):  
       HN(R 1 )-Q 3 -N(R 2 )-T 1 -Q 4   (4)  
     wherein 
 R 1  and R 2 , independently of each other, represent a hydrogen atom, hydroxyl group, alkyl group or alkoxy group;  
 T 1  represents a carbonyl or sulfonyl group;  
 Q 4  represents a saturated or unsaturated, bicyclic or tricyclic hydrocarbon group which may be substituted, or a saturated or unsaturated, bicyclic or tricyclic fused heterocyclic group which may be substituted; and  
 Q 3  represents  
                     
 wherein  
 Q 5  represents an alkylene group having 1 to 8 carbon atoms or an alkenylene group having 2 to 8 carbon atoms; and  
 R 9  and R 10  are substituents on carbon atoms(s) of a ring comprising Q 5  and represent, independently of each other, a hydrogen atom, hydroxyl group, alkyl group, alkenyl group, alkynyl group, halogen atom, halogenoalkyl group, cyano group, cyanoalkyl group, amino group, aminoalkyl group, N-alkylaminoalkyl group, N,N-dialkylaminoalkyl group, acyl group, acylalkyl group; acylamino group which may be substituted, alkoxyimino group, hydroxyimino group, acylaminoalkyl group, carboxyl group, carboxyalkyl group, alkoxycarbonyl group, alkoxycarbonylalkyl group, alkoxycarbonylalkylamino group, carboxyalkylamino group, alkoxycarbonylamino group, alkoxycarbonylaminoalkyl group, carbamoyl group, N-alkylcarbamoyl group which may have a substituent on the alkyl group, N-alkenylcarbamoylalkyl group, N-alkenyl-N-alkylcarbamoyl group, N-alkenyl-N-alkylcarbamoylalkyl group, N-alkoxycarbamoylalkyl group, N-alkyl-N-alkoxycarbamoylalkyl group, carbazoyl group which may be substituted by 1 to 3 alkyl groups, alkylsulfonyl group, alkylsulfonylalkyl group, 3- to 6-membered nitrogen-containing heterocyclic carbonyl group which may be substituted, carbamoylalkyl group, N-alkylcarbamoylalkyl group which may have a substituent on the alkyl group, N,N-dialkylcarbamoylalkyl group which have a substituent on the alkyl group, carbamoyloxyalkyl group, N-alkylcarbamoyloxyalkyl group, N,N-dialkylcarbamoyl-oxyalkyl group, 3- to 6-membered nitrogen-containing heterocyclic carbonyloxyalkyl group which may be substituted, 3- to 6-membered nitrogen-containing heterocyclic carbonylalkyl group which may be substituted, aryl group, aralkyl group, heteroaryl group, heteroarylalkyl group, alkylsulfonylamino group, arylsulfonylamino group, alkylsulfonylaminocarbonyl group, arylsulfonylaminocarbonyl group, alkylsulfonyl-aminocarbonylalkyl group, arylsulfonylaminocarbonyalkyl group, oxo group, carbamoyloxy group, aralkyloxy group, carboxyalkyloxy group, acyloxy group or acyloxyalkyl group, or  
 R 9  and R 10 , together with each other, represent an alkylene group having 1 to 5 carbon atoms, alkenylene group having 2 to 5 carbon atoms or carbonyldioxy group;  
 or a salt thereof, a solvate thereof, or an N-oxide thereof.  
 
   
   
       23 . A compound represented by the following general formula (9):  
       Q 1 -Q 2 -C(═O)—N(R 1 )-Q 3 -NHR 2   (9)  
     wherein 
 R 1  and R 2 , independently of each other, represent a hydrogen atom, hydroxyl group, alkyl group or alkoxy group;  
 Q 1  represents a saturated or unsaturated, bicyclic or tricyclic heterocyclic group which may be substituted;  
 Q 2  represents a single bond; and  
 Q 3  represents  
                     
 wherein  
 Q 5  represents an alkylene group having 1 to 8 carbon atoms or an alkenylene group having 2 to 8 carbon atoms; and  
 R 9  and R 10  are substituents on carbon atoms(s) of a ring comprising Q 5  and represent, independently of each other, a hydrogen atom, hydroxyl group, alkyl group, alkenyl group, alkynyl group, halogen atom, halogenoalkyl group, cyano group, cyanoalkyl group, amino group, aminoalkyl group, N-alkylaminoalkyl group, N,N-dialkylaminoalkyl group, acyl group, acylalkyl group, acylamino group which may be substituted, alkoxyimino group, hydroxyimino group, acylaminoalkyl group, carboxyl group, carboxyalkyl group, alkoxycarbonyl group, alkoxycarbonylalkyl group, alkoxycarbonylalkylamino group, carboxyalkylamino group, alkoxycarbonylamino group, alkoxycarbonylaminoalkyl group, carbamoyl group, N-alkylcarbamoyl group which may have a substituent on the alkyl group, N-alkenylcarbamoylalkyl group, N-alkenyl-N-alkylcarbamoyl group, N-alkenyl-N-alkylcarbamoylalkyl group, N-alkoxycarbamoylalkyl group, N-alkyl-N-alkoxycarbamoylalkyl group, carbazoyl group which may be substituted by 1 to 3 alkyl groups, alkylsulfonyl group, alkylsulfonylalkyl group, 3- to 6-membered nitrogen-containing heterocyclic carbonyl group which may be substituted, carbamoylalkyl group, N-alkylcarbamoylalkyl group which may have a substituent on the alkyl group, N,N-dialkylcarbamoylalkyl group which have a substituent on the alkyl group, carbamoyloxyalkyl group, N-alkylcarbamoyloxyalkyl group, N,N-dialkylcarbamoyl-oxyalkyl group, 3- to 6-membered nitrogen-containing heterocyclic carbonyloxyalkyl group which may be substituted, 3- to 6-membered nitrogen-containing heterocyclic carbonylalkyl group which may be substituted, aryl group, aralkyl group, heteroaryl group, heteroarylalkyl group, alkylsulfonylamino group, arylsulfonylamino group, alkylsulfonylaminocarbonyl group, arylsulfonylaminocarbonyl group, alkylsulfonyl-aminocarbonylalkyl group, arylsulfonylaminocarbonyalkyl group, oxo group, carbamoyloxy group, aralkyloxy group, carboxyalkyloxy group, acyloxy group or acyloxyalkyl group, or  
 R 9  and R 10 , together with each other, represent an alkylene group having 1 to 5 carbon atoms, alkenylene group having 2 to 5 carbon atoms or carbonyldioxy group;  
 or a salt thereof, a solvate thereof, or an N-oxide thereof.