Microfludic devices with new inner surfaces

Abstract

A microfluidic disc having one or more enclosed microchannel structures, and the microchannel structures are intended to be used for transport of transporting liquids. The device is characterized in that at least a part of the inner walls of each of one or more microchannel structures are treated with a gas plasma having one or more organic precursor compounds.

1 - 17 . (canceled)  
     
     
         18 . A microfluidic device comprising one or more enclosed microchannel structures, each of which comprises a section that is defined between two essentially planar substrates wherein one surface in at least one substrate comprises microstructures in the form of grooves or projections that match each other so that they together define said section one or more microchannel structures when the two surfaces are apposed in the microfluidic device, said microchannel structures being intended for transporting a liquid, wherein a) a non-wettable and a wettable coat are present edge-to-edge in at least one of the microchannel structures, b) at least one of the coats has been introduced by the use of a gas plasma comprising an organic precursor compound, and c) the non-wettable coat defines a valve function or a non-wicking function or a vent function to ambient atmosphere.  
     
     
         19 . The microfluidic device of  claim 18 , wherein said section comprises a complete microchannel structure.  
     
     
         20 . The microfluidic device of  claim 18 , wherein wettable coat has a water contact angle that is ≦40°.  
     
     
         21 . The microfluidic device of  claim 18 , wherein the non-wettable coat has a water contact angle that is ≧100°.  
     
     
         22 . The microfluidic device of  claim 18 , wherein the coat is anti-fouling with respect to bovine serum albumin with a decrease ratio that is ≦0.50.  
     
     
         23 . The microfluidic device of claim  13 , wherein the wettable coat has a water contact angle that is ≦60°.  
     
     
         24 . The microfluidic device of claim  13 , wherein the wettable coat is anti-fouling with respect to bovine serum albumin.with a decrease ratio ≦0.75.  
     
     
         25 . The microfluidic device of claim  13 , wherein the difference in wettability between the coats ≧50°.  
     
     
         26 . The microfluidic device of claim  13 , wherein the non-wettable coat has a water contact angle that is ≧90°.