Method of treating lower urinary tract disorders

Abstract

The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT 3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis, comprising coadministering to said subject a first amount of a 5-HT 3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount.

1 - 70 . (canceled)  
     
     
         71 . Use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine or a salt thereof for the manufacture of a medicament for the treatment of urinary incontinence.  
     
     
         72 . Use according to  claim 71 , wherein the salt is the monohydrate hydrochloride.  
     
     
         73 . Use according to  claim 71  or  claim 72 , wherein the urinary incontinence is stress urinary incontinence.  
     
     
         74 . A method for the treatment of urinary incontinence in a patient suffering therefrom, comprising administering to the patient an effective amount of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine or a salt thereof.  
     
     
         75 . The method according to  claim 74 , wherein the salt is the monohydrate hydrochloride.  
     
     
         76 . The method according to  claim 74  or  claim 75 , wherein the urinary incontinence is stress urinary incontinence.