Adipocyte complement related protein zacrp13

Abstract

The present invention relates to polynucleotide and polypeptide molecules for zacrp13, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. Novel zacrp13 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp13 protein or fragments thereof.

1 . An isolated polypeptide comprising amino acid residues 18-459 of SEQ ID NO:2.  
     
     
         2 . The isolated polypeptide of  claim 1  further comprising a signal sequence.  
     
     
         3 . The isolated polypeptide of  claim 2  wherein the signal sequence comprises amino acid residues 1-17 of SEQ ID NO:2.  
     
     
         4 . The isolated polypeptide of  claim 1  wherein the polypeptide is recombinant.  
     
     
         5 . The isolated polypeptide of  claim 4  wherein the recombinant polypeptide is produced in a prokaryotic cell.  
     
     
         6 . The isolated polypeptide of  claim 5  wherein the recombinant polypeptide is produced in  E. coli.    
     
     
         7 . The isolated polypeptide of  claim 4  wherein the recombinant polypeptide is produced in a eukaryotic cell.  
     
     
         8 . The isolated polypeptide of  claim 7  wherein the recombinant polypeptide is produced in a mammalian cell.  
     
     
         9 . The isolated polypeptide of  claim 7  wherein the recombinant polypeptide is produced in a Chinese hamster ovary cell.  
     
     
         10 . The isolated polypeptide of  claim 1  further comprising an affinity tag.  
     
     
         11 . An isolated polypeptide consisting of amino acid residues 18-459 of SEQ ID NO:2.