US2005281897A1PendingUtilityA1

Agent for preventing, improving or treating hypertension

65
Assignee: KAO CORPPriority: Sep 5, 2000Filed: Aug 24, 2005Published: Dec 22, 2005
Est. expirySep 5, 2020(expired)· nominal 20-yr term from priority
Inventors:Atsushi SuzukiRyuji OchiaiIchiro Tokimitsu
A61K 36/82A61K 36/67A61K 36/81A61P 9/12A61K 31/19A61K 36/906A61K 31/192
65
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Claims

Abstract

The invention relates to an agent for preventing, improving or treating hypertension, which exhibits a hypotensive effect, inhibits the rise of blood pressure and improves hypertension, and food for preventing or improving hypertension, which does not become a burden in daily intake, has a higher antihypertensive effect and is useful as a diet during treatment for patients of hypertension. The agent for preventing, improving or treating hypertension contains the following components (A) and (B): (A) a compound selected from the group consisting of caffeic acid, chlorogenic acid and ferulic acid, and esters and pharmaceutically acceptable salts thereof; and (B) a component selected from the group consisting of central nervous system stimulating components, food fibers, extracts of perennial evergreen leaves of the genus Camellia, Theaceae , or Eucommia ulmoides Oliver, Eucommiae , organic acids having a molecular weight of 60 to 300 (excluding citric acid) and pharmaceutically acceptable salts thereof, and sugar alcohols.

Claims

exact text as granted — not AI-modified
1 - 6 . (canceled)  
   
   
       7 . A method for treating hypertension comprising: 
 administering a composition comprising:    (A) at least one isolated caffeic acid, chlorogenic acid, or ferulic acid, or an ester or salt of said acid(s); and    (B) at least one component selected from the group consisting of:    (i) a heat component of  Zingiberaceae, Capsicum  or  Piperaceae,      (ii) a food fiber,    (iii) an extract of perennial evergreen leaves of the genus  Camillia, Theaceae , or  Eucommia,      (iv) an organic acid having a molecular weight ranging from 60 to 300 or a pharmaceutically acceptable salt thereof, and    (v) a sugar alcohol.    
   
   
       8 . The method of  claim 7 , wherein (A) is caffeic acid or an ester or salt thereof.  
   
   
       9 . The method of  claim 7 , wherein (A) is chlorogenic acid or an ester or salt thereof.  
   
   
       10 . The method of  claim 7 , wherein (A) is ferulic acid or an ester or salt thereof.  
   
   
       11 . The method of  claim 7 , wherein (B) comprises (i) a heat component of  Zingiberaceae, Capsicum  or  Piperaceae.    
   
   
       12 . The method of  claim 7 , wherein (B) comprises(ii) a food fiber.  
   
   
       13 . The method of  claim 7 , wherein (B) comprises (iii) an extract of perennial evergreen leaves of the genus  Camillia, Theaceae , or  Eucommia.    
   
   
       14 . The method of  claim 7 , wherein (B) comprises (iv) an organic acid having a molecular weight ranging from 60 to 300 or a pharmaceutically acceptable salt thereof.  
   
   
       15 . The method of  claim 7 , wherein (B) comprises (v) a sugar alcohol.  
   
   
       16 . A composition comprising: 
 (A) at least one isolated caffeic acid, chlorogenic acid, or ferulic acid, or an ester or salt of said acid(s); and    (B) at least one component selected from the group consisting of:    (i) a heat component of  Zingiberaceae, Capsicum  or  Piperaceae,      (ii) a food fiber,    (iii) an extract of perennial evergreen leaves of the genus  Camillia, Theaceae , or  Eucommia,      (iv) an organic acid having a molecular weight ranging from 60 to 300 or a pharmaceutically acceptable salt thereof, and    (v) a sugar alcohol.    
   
   
       17 . The composition of  claim 16 , wherein (A) is caffeic acid or an ester or salt thereof.  
   
   
       18 . The composition of  claim 16 , wherein (A) is chlorogenic acid or an ester or salt thereof.  
   
   
       19 . The composition of  claim 16 , wherein (A) is ferulic acid or an ester or salt thereof.  
   
   
       20 . The composition of  claim 16 , wherein (B) comprises (i) a heat component of  Zingiberaceae, Capsicum  or  Piperaceae.    
   
   
       21 . The composition of  claim 16 , wherein (B) comprises (ii) a food fiber.  
   
   
       22 . The composition of  claim 16 , wherein (B) comprises (iii) an extract of perennial evergreen leaves of the genus  Camillia, Theaceae , or  Eucommia.    
   
   
       23 . The composition of  claim 16 , wherein (B) comprises (iv) an organic acid having a molecular weight ranging from 60 to 300 or a pharmaceutically acceptable salt thereof.  
   
   
       24 . The composition of  claim 16 , wherein (B) comprises (v) a sugar alcohol.  
   
   
       25 . A food supplemented with the composition of  claim 16 .  
   
   
       26 . A drink supplemented with the composition of  claim 16.

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