US2005263455A1PendingUtilityA1

Processing of chemicals in flow-through device with porous media

45
Individually held — no corporate assignee on recordPriority: May 1, 2002Filed: May 16, 2005Published: Dec 1, 2005
Est. expiryMay 1, 2022(expired)· nominal 20-yr term from priority
Inventors:Shahnaz JamalabadiPeter C. RahnKelvin HammondOmar MneimneJeffrey A. Horsman
B01J 20/286B01D 15/16G01N 30/12B01D 15/22B01D 15/20B01J 20/3242G01N 2030/121B01J 2219/1227B01D 15/3857H05B 6/806G01N 2030/3046B01J 19/126B01J 20/281G01N 30/06B01J 2220/54G01N 30/6091
45
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Claims

Abstract

A method of processing a sample comprising introducing a sample into a flow-through device containing a porous solid media therein, and thereafter subjecting the device to microwave energy.

Claims

exact text as granted — not AI-modified
1 . A method of processing a sample comprising 
 introducing a sample into a flow-through device containing a porous solid media therein, and    thereafter subjecting the device to microwave energy.    
     
     
         2 . The method of  claim 1  wherein said introducing said sample includes introducing said sample with a solvent to said flow-through device.  
     
     
         3 . The method of  claim 2  wherein said solvent is evaporated during said subjecting the device to microwave energy.  
     
     
         4 . The method of  claim 3  wherein said media is a chromatographic media.  
     
     
         5 . The method of  claim 1  wherein said sample includes reagents that undergo a chemical reaction to form a reaction product during said subjecting the device to microwave energy.  
     
     
         6 . The method of  claim 5  wherein said solid media includes scavengers attached to said solid media to remove excess reagents.  
     
     
         7 . The method of  claim 6  wherein said scavengers are electrophile scavengers.  
     
     
         8 . The method of  claim 7  wherein said electrophile scavengers are selected from the group consisting of amino scavengers, TsNHNH2 scavengers, and SH scavengers.  
     
     
         9 . The method of  claim 6  wherein said scavengers are nucleophile scavengers.  
     
     
         10 . The method of  claim 9  wherein said nucleophile scavengers are selected from the group consisting of TsCl scavengers and NCO scavengers.  
     
     
         11 . The method of  claim 6  wherein said scavengers are base scavengers.  
     
     
         12 . The method of  claim 11  wherein said base scavenger is a quaternary amine scavenger.  
     
     
         13 . The method of  claim 6  wherein said scavengers are acid scavengers.  
     
     
         14 . The method of  claim 13  wherein said acid scavengers are selected from the group consisting of TsOH scavengers and COOH scavengers.  
     
     
         15 . The method of  claim 5  wherein said solid media includes coupling agents attached to said solid media.  
     
     
         16 . The method of  claim 15  wherein said coupling agents are selected from the group consisting of DCC coupling agents, HOBt coupling agents, and NHS coupling agents.  
     
     
         17 . The method of  claim 5  wherein said solid media includes a catalyst attached to said solid media.  
     
     
         18 . The method of  claim 17  wherein said catalyst is TSOH.  
     
     
         19 . The method of  claim 5  wherein said solid media includes a catalyst remover attached to said solid media.  
     
     
         20 . The method of  claim 19  wherein said catalyst remover is DEAM.  
     
     
         21 . A method of processing a sample comprising 
 introducing a sample into a flow-through device containing a porous solid media therein and active components attached to said solid media, and    thereafter subjecting the device to microwave energy, heat or UV energy in order to accelerate reactions implemented by said active components, said reactions resulting in a reaction product created from said sample.    
     
     
         22 . The method of  claim 21  further comprising thereafter transferring said reaction product from said flow-through device to a chromatography column.  
     
     
         23 . A method of processing a sample comprising 
 introducing reagents into a flow-through device containing a porous solid media therein and active components attached to said solid media,    causing a synthesis reaction involving said reagents in said flow-through device and resulting in a reaction product,    thereafter placing said flow-through device into an entrance region within a chromatography column, and    thereafter carrying out chromatography on said reaction product.    
     
     
         24 . The method of  claim 23  further comprising subjecting the device to microwave energy during said causing step.  
     
     
         25 . (canceled)  
     
     
         26 . (canceled)  
     
     
         27 . (canceled)  
     
     
         28 . The method of  claim 21 , wherein said active components are at least one member selected from the group consisting of scavengers, coupling agents, catalysts, and catalyst removers.  
     
     
         29 . (canceled)  
     
     
         30 . A method of processing a sample comprising 
 introducing a sample into a flow-through device containing a porous solid media therein, and    thereafter subjecting the device to a radiated energy source.    
     
     
         31 . The method of  claim 30  wherein said radiated energy source provides microwave energy.  
     
     
         32 . The method of  claim 30  wherein said radiated energy source provides ultra-violet energy.  
     
     
         33 . The method of  claim 30  wherein said radiated energy source provides sonic energy.  
     
     
         34 . A method of processing a sample comprising 
 introducing a sample into a flow-through device containing a porous solid media therein and active components attached to said solid media, and    thereafter subjecting the device to energy in order to accelerate or promote reactions implemented by said active components, said reactions resulting in a reaction product created from said sample.    
     
     
         35 . A method of processing a sample comprising 
 introducing a sample into a flow-through device containing a porous solid media therein and active components attached to said solid media, said device having a liquid receiving region above said media,    carrying out a reaction on said sample using said active components, and    adding wash solvent to said liquid receiving region.    
     
     
         36 . A method of processing a sample comprising 
 introducing reagents into a flow-through device containing a porous solid media therein and active components attached to said solid media,    causing a chemical reaction involving said reagents in said flow-through device and resulting in a reaction product,    thereafter placing said flow-through device into fluid flow communication with a chromatography column, and    thereafter carrying out chromatography on said reaction product.    
     
     
         37 . The method of  claim 36  further comprising subjecting the device to energy in order to accelerate or promote said chemical reaction.  
     
     
         38 . The method of  claim 36  wherein said device is placed into said chromatography column.  
     
     
         39 . The method of  claim 36  wherein said device is connected to said chromatography column by a tube.  
     
     
         40 . (canceled)  
     
     
         41 . (canceled)  
     
     
         42 . (canceled)  
     
     
         43 . (canceled)  
     
     
         44 . (canceled)

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