Pharmaceutical formulation

Abstract

Pharmaceutical formulations comprising amoxycillin and clavulante in a ratio of from 10:1 to 20:1 are of use in the emperic treatment of infections potentially caused by DRSP.

1 - 15 . (canceled)  
   
   
       16 . A container comprising a powder or granular product for reconstitution into a suspension or solution upon the addition of water prior to use, said product comprising amoxycillin and clavulanate, wherein the concentration of the amoxycillin in the reconstituted suspension or solution is about 600 mg/5 ml and the ratio of amoxycillin to clavulanate is 14:1+/5%.  
   
   
       17 . The container as claimed in  claim 16  wherein the amount of clavulanate is about 43 mg/5 ml.  
   
   
       18 . The container as claimed in  claim 16  where upon the addition of water contains about 100 ml reconstituted suspension or solution.  
   
   
       19 . The container as claimed in  claim 16  in which amoxycillin is in the form of amoxycillin trihydrate.  
   
   
       20 . The container as claimed in  claim 16  in which amoxycillin is in the form of crystalline sodium amoxycillin.  
   
   
       21 . The container as claimed in  claim 16  in which clavulanate is in the form of potassium clavulanate.  
   
   
       22 . The container as claimed in  claim 16  which further comprises an edible desiccant.  
   
   
       23 . The container as claimed in  claim 22  wherein the desiccant is silicon dioxide.  
   
   
       24 . The container as claimed in  claim 16  which further comprises at least one of a diluent, a suspending agent, a glidant, a bulking agent, a flavour, a sweetener and a stabilizer.  
   
   
       25 . The container as claimed in  claim 24  wherein the suspending agent is xanthan gum and hydroxypropylmethyl cellulose, or a mixture thereof; the glidant is colloidal silica; the stabilizer is succinic acid; the sweetener aspartame; and the bulking agent is silicon dioxide.  
   
   
       26 . The container as claimed in  claim 24  wherein the flavour is selected from banana, raspberry, orange, golden syrup, or mixtures thereof.  
   
   
       27 . The container as claimed in  claim 16  wherein the reconstituted solution is a flavoured aqueous syrup.  
   
   
       28 . The container as claimed in  claim 16  which comprises the reconstituted suspension or solution.  
   
   
       29 . The container as claimed in  claim 16  which is moisture proof.  
   
   
       30 . A container comprising a powder or granular product for reconstitution into a suspension or solution upon the addition of water prior to use, said product comprising amoxycillin and clavulanate, wherein the concentration of clavulanate when reconstituted is from about 35 to 50 mg/5 ml and the ratio of amoxycillin to clavulanate is 14:1+/5%.  
   
   
       31 . The container as claimed in  claim 30  wherein the amount of clavulanate in the product is about 43 mg/5 ml.  
   
   
       32 . The container as claimed in  claim 30  wherein the amount of amoxycillin in the product is from about 500 to 700 mg/5 ml.  
   
   
       33 . The container as claimed in  claim 30  where upon the addition of water contains 100 ml reconstituted suspension or solution.  
   
   
       34 . The container as claimed in  claim 30  in which the amoxycillin in the product is in the form of amoxycillin trihydrate.  
   
   
       35 . The container as claimed in  claim 30  in which the amoxycillin in the product is in the form of crystalline sodium amoxycillin.  
   
   
       36 . The container as claimed in  claim 30  in which the clavulanate in the product is in the form of potassium clavulanate.  
   
   
       37 . The container as claimed in  claim 30  which product further comprises an edible desiccant.  
   
   
       38 . The container as claimed in  claim 37  wherein the desiccant is silicon dioxide.  
   
   
       39 . The container as claimed in claim  301  which product further comprises at least one of a diluent, a suspending agent, a glidant, a bulking agent, a flavour, a sweetener and a stabilizer.  
   
   
       40 . The container as claimed in  claim 39  wherein the suspending agent is xanthan gum and hydroxypropylmethyl cellulose, or a mixture thereof; the glidant is colloidal silica; the stabilizer is succinic acid; the sweetener aspartame; and the bulking agent is silicon dioxide.  
   
   
       41 . The container as claimed in  claim 30  wherein the reconstituted solution is a flavoured aqueous syrup.  
   
   
       42 . The container as claimed in  claim 39  wherein the flavour is selected from banana, raspberry, orange, golden syrup, or mixtures thereof.  
   
   
       43 . The container as claimed in  claim 30  which is moisture proof.