Receptor for Oncostatin M

Abstract

A novel polypeptide functions as the β chain of an oncostatin M receptor and is thus designated OSM-Rβ. Heterodimeric receptor proteins comprising OSM-Rβ and gp130 bind oncostatin M and find use in inhibiting biological activities mediated by oncostatin M.

1 - 36 . (canceled)  
     
     
         37 . An antibody that specifically binds to a heterodimeric receptor comprising a gp130 polypeptide covalently or non-covalently linked to an oncostatin M receptor β-chain (OSM-Rβ) polypeptide, wherein: 
 a) said gp130 polypeptide comprises amino acids 1 to 686 of SEQ ID NO: 2 or a fragment thereof; and    b) said OSM-Rβ polypeptide comprises amino acids 1 to 952 of SEQ ID NO: 6 or a fragment thereof.    
     
     
         38 . An antibody that specifically binds to the extracellular domains of a heterodimeric receptor comprising a gp 130 polypeptide covalently or non-covalently linked to an oncostatin M receptor β-chain (OSM-Rβ) polypeptide, wherein: 
 c) said gp130 polypeptide comprises amino acids 1 to 567 of SEQ ID NO: 2 or a fragment thereof; and    d) said OSM-Rβ polypeptide comprises amino acids 1 to 714 of SEQ ID NO: 6 or a fragment thereof.    
     
     
         39 . The antibody of  claim 38 , wherein said gp130 polypeptide comprises amino acids 1 to y of SEQ ID NO: 2, wherein y represents an integer between 1 and 567 inclusive, and said OSM-Rβ polypeptide comprises amino acids 1 to x of SEQ ID NO: 6, wherein x is an integer between 1 and 714 inclusive.  
     
     
         40 . An antibody that specifically binds to a heterodimeric receptor comprising a gp130 polypeptide covalently linked to an oncostatin M receptor β-chain (OSM-Rβ) polypeptide, wherein the OSM-Rβ polypeptide is encoded by a nucleic acid selected from the group consisting of DNA capable of hybridizing to the DNA of the coding region of SEQ ID NO: 5 under highly stringent conditions that include hybridization at 68° C. followed by washing in 0.1×SSC/0.1% SDS at 63-68° C.