Preparation and use of imidazole derivatives for treatment of obesity

Abstract

This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

1 - 118 . (canceled)  
   
   
       119 . A method of treating obesity-related disorders comprising the step of administering to a patient in need thereof a pharmaceutically effective amount of 1-(4-chlorophenyl)-2-(2-chlorophenyl)-N-(1-piperidinyl)-5-ethyl-1H-imidazole-4-carboxamide, or pharmaceutical salts and esters thereof.  
   
   
       120 . The method of  claim 119 , wherein said obesity-related disorders include dyslipidernia, hypertriglyceridemia, hypertension, diabetes, Syndrome X, atherosclerotic disease, cardiovascular disease, cerebrovascular disease, peripheral vessel disease, cholesterol gallstones, cancer, menstrual abnormalities, infertility, polycystic ovaries, osteoarthritis, and sleep apnea.  
   
   
       121 . A method of regulating appetite and food intake comprising the step of administering to a patient in need thereof a pharmaceutically effective amount of 1-(4-chlorophenyl)-2-(2-chlorophenyl)-N-(1-piperidinyl)-5-ethyl-1H-imidazole-4-carboxamide, or pharmaceutical salts and esters thereof.  
   
   
       122 . A method of treating bulimia comprising the step of administering to a patient in need thereof a pharmaceutically effective amount of 1-(4-chlorophenyl)-2-(2- chlorophenyl)-N-(1-piperidinyl)-5-ethyl-1H-imidazole-4-carboxamide, or pharmaceutical salts and esters thereof.  
   
   
       123 . A method of treating obesity and obesity-related disorders comprising the step of administering to a patient in need thereof a pharmaceutically effective amount of 1-(4-chlorophenyl)-2-(2-chlorophenyl)-N-(1-piperidinyl)-5-ethyl-1H-imidazole4-carboxamide, or pharmaceutical salts and esters thereof, in combination with one or more agents that modulate digestion and/or metabolism.  
   
   
       124 . The method of  claim 123 , wherein said obesity-related disorders include dyslipidemia, hypertriglyceridemia, hypertension, diabetes, Syndrome X, atherosclerotic disease, cardiovascular disease, cerebrovascular disease, peripheral vessel disease, cholesterol gallstones, cancer, menstrual abnormalities, infertility, polycystic ovaries, osteoarthritis, and sleep apnea.  
   
   
       125 . The method of  claim 123 , wherein said agents that modulate digestion and/or metabolism are selected from the group consisting of agents that modulate thernogenesis, lipolysis, gut motility, fat absorption, and satiety.  
   
   
       126 . The method of  claim 124 , wherein said agents that modulate digestion and/or metabolism are selected from the group consisting of agents that modulate thermogenesis, lipolysis, gut motility, fat absorption, and satiety.  
   
   
       127 . The method of  claim 123 , wherein said agent that modulates digestion and/or metabolism is a β 3 -adrenoreceptor agent.  
   
   
       128 . The method of  claim 124 , wherein said agent that modulates digestion and/or metabolism is a β 3 -adrenoreceptor agent.  
   
   
       129 . A method of treating obesity and obesity-related disorders comprising the step of administering to a patient in need thereof a pharmaceutically effective amount of 1-(4-chlorophenyl)-2-(2-chlorophenyl)-N-(1-piperidinyl)-5-ethyl-1H-imidazole-4-carboxarnide, or pharmaceutical salts and esters thereof, in combination with one or more agents selected from the group consisting of HMG CoA reductase inhibitor, bile acid binding agent, fibric acid derivative, and agent that regulates hypertension.  
   
   
       130 . The method of  claim 129 , wherein said obesity-related disorders include dyslipidemia, hypertriglyceridemia, hypertension, diabetes, Syndrome X, atherosclerotic disease, cardiovascular disease, cerebrovascular disease, peripheral vessel disease, cholesterol gallstones, cancer, menstrual abnormalities, infertility, polycystic ovaries, osteoarthritis, and sleep apnea.