Remedies for glomerular diseases

Abstract

The present invention relates to a preventive or therapeutic agent for a glomerular disease which comprises an anti-thrombocytic agent and an HMG-CoA reductase inhibitor as active ingredients. The above agent is useful for prevention and therapy of various glomerular diseases including chronic glomerular nephritis.

1 . A preventive or therapeutic agent for a glomerular disease which comprises an anti-thrombocytic agent and an HMG-CoA reductase inhibitor as active ingredients.  
   
   
       2 . The preventive or therapeutic agent for a glomerular disease according to  claim 1 , wherein the anti-thrombocytic agent has an adenosine enhancing function or a phospholipase inhibiting function.  
   
   
       3 . The preventive or therapeutic agent for a glomerular disease according to  claim 1  or  2 , wherein the anti-thrombocytic agent is a drug selected from the group consisting of dilazep, dipyridamole, trimetazidine and trapidil and salts thereof.  
   
   
       4 . The preventive or therapeutic agent for a glomerular disease according to  claim 1  or  2 , wherein the anti-thrombocytic agent is dilazep or a salt thereof.  
   
   
       5 . The preventive or therapeutic agent for a glomerular disease according to any one of  claims 1  to  4 , wherein the HMG-CoA reductase inhibitor is a drug selected from the group consisting of lovastatin, simvastatin, pravastatin, fluvastatin, cerivastatin, atorvastatin, rosuvastatin and pitavastatin and salts thereof.  
   
   
       6 . The preventive or therapeutic agent for a glomerular disease according to any one of  claims 1  to  4 , wherein the HMG-CoA reductase inhibitor is pitavastatin or a salt thereof.  
   
   
       7 . The preventive or therapeutic agent for a glomerular disease according to any one of  claims 1  to  6 , containing the anti-thrombocytic agent and the HMG-CoA reductase inhibitor in a single formulation.  
   
   
       8 . The preventive or therapeutic agent for a glomerular disease according to any one of  claims 1  to  6 , being a kit comprising the anti-thrombocytic agent and the HMG-CoA reductase inhibitor in the form of separate formulations.  
   
   
       9 . A pharmaceutical composition for preventing or treating a glomerular disease, which comprises an anti-thrombocytic agent, an HMG-CoA reductase inhibitor, and a pharmaceutically acceptable carrier.  
   
   
       10 . Use of an anti-thrombocytic agent and an HMG-CoA reductase inhibitor for producing a preventive or therapeutic agent for a glomerular disease.  
   
   
       11 . A method for treating a glomerular disease, which comprises administering an anti-thrombocytic agent and an HMG-CoA reductase inhibitor.