Use of creatine analogues and creatine kinase modulators for the prevention and treatment of glucose metabolic disorders

Abstract

The present invention relates to the use of creatine compounds including cyclocreatine and creatine phosphate for treating or preventing a metabolic disorder consisting of hyperglycemia, insulin dependent diabetes mellitus, impaired glucose tolerance, hyperinsulinemia, insulin insensitivity, diabetes related diseases in a patient experiencing said disorder. The creatine compounds which can be used in the present method include (1) analogues of creatine which can act as substrates or substrate analogues for the enzyme creatine kinase; (2) compounds which can act as activators or inhibitors of creatine kinase; (3) compounds which can modulate the creatine transporter (4) N-phosphocreatine analogues bearing transferable or non-transferable moieties which mimic the N-phosphoryl group. (5) compounds which modify the association of creatine kinase with other cellular components.

1 . A process for designing analogues of cyclocreatine and creatine phosphate effective for the treatment of diseases related to glucose level regulation comprising utilizing creatine kinase structural coordinates as a basis for said analogues and chemically modifying said coordinates to achieve a pharmacologically active analogue.