External preparation

Abstract

An external preparation composition used for preventing or treating symptoms or diseases related to dermatopathy caused by dryness, UV rays and aging such as wrinkles and sags of the skin, pigmentation of the skin, skin roughness and coarse texture and skin diseases such as psoriasis, lichen, ichthyosis, keratosis, Darier's disease, pustulosis, acne, eczema and atopic dermatitis. The external preparation composition comprises at least one of acyl glucosamine derivatives represented by the following Formula (I): wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined; and X is any one of groups represented by the following Formulas (A) to (C): wherein Y, n and R 6 are also defined.

1 . An external preparation composition comprising at least one of acyl glucosamine derivatives represented by the following Formula (I):  
     
       
         
         
             
             
         
       
       wherein R 1 , R 2 , R 3  and R 4  represent a hydrogen atom, a saturated or unsaturated, linear or branched fatty acid residue having 2 to 36 carbon atoms or a linear or branched alkyl group having 1 to 4 carbon atoms which may have a hydroxyl group, and they may be the same or different each other; R 5  represents a hydrogen atom or a linear or branched alkyl group having 1 to 4 carbon atoms which may have a hydroxyl group; X is any one of groups represented by the following Formulas (A) to (C):  
       
         
           
           
               
               
           
         
       
       wherein Y in (A) and (B) represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms in which an ether group may be interposed into a bond; and n represents an integer of 0 to 10; and R 6  represents a linear or branched alkyl group or alkenyl group having 11 to 36 carbon atoms which may have a substituent.  
     
   
   
       2 . The external preparation composition as described in  claim 1 , wherein it is used as at least one of a wrinkle-improving agent, a coarse texture-improving agent, a skin roughness-improving agent a whitening agent and a acne-improving agent.  
   
   
       3 . The external preparation composition as described in  claim 2 , comprising a percutaneous absorption accelerator and/or a chemically active substance having a skin care effect.  
   
   
       4 . The external preparation composition as described in  claim 3 , further comprising a silicone oil and a silicone derivative.  
   
   
       5 . The external preparation composition as described in  claim 1 , further comprising a silicone oil and a silicone derivative.  
   
   
       6 . The external preparation composition as described in  claim 2 , further comprising a silicone oil and a silicone derivative.  
   
   
       7 . The external preparation composition as described in  claim 3 , further comprising a silicone oil and a silicone derivative.  
   
   
       8 . The external preparation composition as described in  claim 1 , comprising a percutaneous absorption accelerator and/or a chemically active substance having a skin care effect.