Regulation of human transketolase-like enzyme

Abstract

Reagents which regulate human transketolase-like enzyme and reagents which bind to human transketolase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including but not limited to, cancer, anemia, and end-stage renal disease, including sensory periphery neuropathy associated with uremia.

1 - 75 . (canceled)  
     
     
         76 . A method of screening for candidate therapeutic agents, comprising the steps of: 
 assaying for expression of a polynucleotide encoding a protein comprising the amino acid sequence shown in SEQ ID NO:2 in the presence and absence of a test compound; and    identifying a test compound that regulates the expression as a candidate therapeutic agent that may be useful for treating a disorder associated with aberrant expression of the polynucleotide.    
     
     
         77 . The method of  claim 76  wherein the step of contacting is in a cell.  
     
     
         78 . The method of  claim 76  wherein the step of contacting is in a cell-free in vitro translation system.