Processes for the preparation of 1,5-diryl-3-substituted-pyrazoles

Abstract

Provided are processes and chemical intermediates useful for preparing a compound of the formula I wherein X is selected from the group consisting of C 1 -C 6 trihalomethyl; C 1 -C 6 alkyl; and an optionally substituted or di-substituted phenyl group of formula II: Y and Z are independently selected from the group consisting of substituted and unsubstituted aryl.

1 - 26 . (canceled)  
     
     
         27 . A compound of the formula III  
       
         
           
           
               
               
           
         
       
       wherein Z is selected from the group consisting of substituted and unsubstituted aryl.  
     
     
         28 . The compound of  claim 27 , wherein Z is substituted or unsubstituted heteroaryl.  
     
     
         29 . The compound of  claim 28 , wherein Z is selected from the group consisting of substituted and unsubstituted indolyl, furyl, thienyl, pyridyl, benzofuryl, benzothienyl, imidazolyl, pyrazolyl, thiazolyl, benzothiazolyl, quinolinyl, and 4-(2-benzyloxazolyl).  
     
     
         30 . The compound of  claim 29 , wherein Z is 3-indolyl.  
     
     
         31 . The compound of  claim 27 , wherein Z is selected from the group consisting of unsubstituted phenyl, mono-, di-, and trisubstituted phenyl.  
     
     
         32 . The compound of  claim 31 , wherein Z is phenyl substituted with one or more of halogen, hydroxyl, nitro, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, carboxy, C 1 -C 6  trihaloalkyl and cyano.  
     
     
         33 . The compound of  claim 32 , wherein Z is p-methylphenyl.  
     
     
         34 - 35 . (canceled)