US2005209342A1PendingUtilityA1

Processes for preparation of polymorphic form II of sertraline hydrochloride

52
Assignee: BOROCHOVITCH RONENPriority: Apr 29, 2002Filed: May 13, 2005Published: Sep 22, 2005
Est. expiryApr 29, 2022(expired)· nominal 20-yr term from priority
Inventors:Ronen BorochovitchMarioara MendeloviciTamar NidamRuth TenengauzerJulia HrakovskyJudith Aronhime
C07C 2602/10C07C 209/84
52
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Claims

Abstract

Provided are processes for preparation of crystalline sertraline hydrochloride Form II substantilly free of other polymorphic forms of sertraline hydrochloride, preferably on an industrial scale.

Claims

exact text as granted — not AI-modified
1 - 39 . (canceled)  
     
     
         40 . A process for the preparation of sertraline hydrochloride polymorphic form II, wherein a solution of sertraline free amine is seeded with some crystals of polymorphic form II and hydrogen chloride is added.  
     
     
         41 . The process of  claim 40 , wherein hydrogen chloride is added as a gas.  
     
     
         42 . A process of  claim 40 , wherein the solution of sertraline free amine is seeded with some crystals of polymorphic form II and subsequently hydrogen chloride is added.  
     
     
         43 . The process of  claim 42 , wherein hydrogen chloride is added as a gas.  
     
     
         44 . A process of  claim 40 , wherein hydrogen chloride is added to the solution of sertraline free amine and subsequently the solution is seeded with some crystals of polymorphic form II.  
     
     
         45 . The process of  claim 44 , wherein hydrogen chloride is added as a gas.

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