US2005209155A1PendingUtilityA1

IGF-binding protein-derived peptide or small molecule

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Assignee: BIOEXPERTISE LLCPriority: Sep 18, 2001Filed: Jan 6, 2005Published: Sep 22, 2005
Est. expirySep 18, 2021(expired)· nominal 20-yr term from priority
Inventors:Desmond Mascarenhas
A61P 3/10A61P 9/10A61P 37/08A61P 35/00A61P 37/02A61P 27/02A61P 25/16A61P 25/00A61P 29/00A61K 38/30A61P 19/08A61P 1/04A61P 19/02A61P 11/06A61K 38/1709C07K 14/4743
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Claims

Abstract

New compositions based on IGF-binding protein sequences are provided. New tools for high-throughput research are provided. New methods for the treatment of human disease are provided. IGFBP-3-derived peptide or small molecule is administered to subjects having disease, thereby alleviating the symptoms of the disease.

Claims

exact text as granted — not AI-modified
1 . A method for alleviating the symptoms of a disease selected from the group consisting of autoimmune disease, cardiovascular indications, arthritis, asthma and allergy, reproductive indications, retinal proliferative disease, bone disease, inflammatory disease, inflammatory bowel disease, and fibrotic disease, comprising administering an effective amount of an IGF-binding protein-derived peptide or small molecule to an individual suffering from said disease.  
     
     
         2 . The method of  claim 1 , wherein said IGF-binding protein-derived peptide or small molecule is administered at about 0.001 to about 40 milligrams per kilogram total body weight per day (mg/kg/day).  
     
     
         3 . The method of  claim 1 , wherein said IGF-binding protein-derived peptide or small molecule is a MBD peptide.  
     
     
         4 . The method of  claim 1 , wherein said MBD peptide comprises the sequence DKKGFYKKKQCRPSKGRKRGFCW (SEQ ID NO:1).  
     
     
         5 . The method of  claim 1 , wherein said MBD peptide comprises the sequence GFYKKKQCRPSKGRKRGFCW (SEQ ID NO:2).  
     
     
         6 . The method of  claim 1 , wherein said MBD peptide comprises the sequence QCRPSKGRKRGFCW (SEQ ID NO:3).  
     
     
         7 . The method of  claim 1 , wherein said MBD peptide comprises the sequence QCRPSKGRKRGFC (SEQ ID NO:8).  
     
     
         8 . The method of  claim 1 , wherein said MBD peptide comprises the sequence CRPSKGRKRGFCW (SEQ ID NO:9).  
     
     
         9 . The method of  claim 1 , wherein said MBD peptide comprises the sequence CRPSKGRKRGFC (SEQ ID NO:4).  
     
     
         10 . The method of  claim 1 , wherein said MBD peptide further comprises a caveolin consensus binding site.  
     
     
         11 . The method of  claim 10 , wherein said MBD peptide comprises the sequence QCRPSKGRKRGFCWAVDKYG (SEQ ID NO:37).  
     
     
         12 . The method of  claim 10 , wherein said MBD peptide comprises the sequence KKGFYKKKQCRPSKGRKRGFCWAVDKYG (SEQ ID NO:38).

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