Inosine compounds and methods of use thereof

Abstract

Inosine compounds, compositions comprising an inosine compound and methods for treating or preventing an inflammation disease or a reperfusion disease comprising administering an effective amount of an inosine compound to a patient in need thereof are disclosed.

1 - 2 . (canceled)  
     
     
         3 . A method for treating or preventing arthritis, comprising administering to a patient in need thereof an effective amount of a compound of formula I:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein: 
 R 1  is C 2 -C 6  acyl, SO 3 H or P 2 O 6 H 3 ; and  
 R 2 , R 3  and R 4  are independently H, C 2 -C 6  acyl, SO 3 H, PO 3 H 2 , P 2 O 6 H 3  or P 3 O 9 H 4 .  
 
     
     
         4 . The method of  claim 3 , wherein R 1  is C 2 -C 6  acyl in the compound of formula I or a pharmaceutically acceptable salt thereof.  
     
     
         5 . The method of  claim 3 , wherein R 1  is  − SO 3 H in the compound of formula I or a pharmaceutically acceptable salt thereof.  
     
     
         6 . The method of  claim 3 , wherein R 1  is P 2 O 6 H 3  in the compound of formula I or a pharmaceutically acceptable salt thereof.  
     
     
         7 . (canceled)  
     
     
         8 . The method of  claim 4 , wherein the C 2 -C 6  acyl is acetyl.  
     
     
         9 - 75 . (canceled)  
     
     
         76 . The method of  claim 5 , wherein R 2 , R 3  and R 4  are each H.  
     
     
         77 . The method of  claim 3 , wherein R 2 , R 3  and R 4  are each H and R 1  is SO 3   − Na + .  
     
     
         78 . The method of  claim 3 , further comprising administering an effective amount of an non-steroidal anti-inflammatory agent.  
     
     
         79 . A method for treating or preventing an inflammatory lung disorder, comprising administering to a patient in need thereof an effective amount of a compound of formula I:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein: 
 R 1  is C 2 -C 6  acyl, SO 3 H or P 2 O 6 H 3 ; and  
 R 2 , R 3  and R 4  are independently H, C 2 -C 6  acyl, SO 3 H, PO 3 H 2 , P 2 O 6 H 3  or P 3 O 9 H 4 .  
 
     
     
         80 . The method of  claim 79 , wherein R 1  is C 2 -C 6  acyl in the compound of formula I or a pharmaceutically acceptable salt thereof.  
     
     
         81 . The method of  claim 79 , wherein R 1  is SO 3 H in the compound of formula I or a pharmaceutically acceptable salt thereof.  
     
     
         82 . The method of  claim 79 , wherein R 1  is P 2 O 6 H 3  in the compound of formula I or a pharmaceutically acceptable salt thereof.  
     
     
         83 . The method of  claim 80 , wherein the C 2 -C 6  acyl is acetyl.  
     
     
         84 . The method of  claim 81 , wherein R 2 , R 3  and R 4  are each H.  
     
     
         85 . The method of  claim 79 , wherein R 2 , R 3  and R 4  are each H and R 1  is SO 3   − Na + .  
     
     
         86 . The method of  claim 89 , further comprising administering an effective amount of an non-steroidal anti-inflammatory agent.  
     
     
         87 . A method for treating or preventing diabetes, comprising administering to a patient in need thereof an effective amount of a compound of formula I:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein: 
 R 1  is C 2 -C 6  acyl, SO 3 H or P 2 O 6 H 3 ; and  
 R 2 , R 3  and R 4  are independently H, C 2 -C 6  acyl, SO 3 H, PO 3 H 2 , P 2 O 6 H 3  or P 3 O 9 H 4 .  
 
     
     
         88 . The method of  claim 87 , wherein R 1  is C 2 -C 6  acyl in the compound of formula I or a pharmaceutically acceptable salt thereof.  
     
     
         89 . The method of  claim 87 , wherein R 1  is SO 3 H in the compound of formula I or a pharmaceutically acceptable salt thereof.  
     
     
         90 . The method of  claim 87 , wherein R 1  is P 2 O 6 H 3  in the compound of formula I or a pharmaceutically acceptable salt thereof.  
     
     
         91 . The method of  claim 87 , wherein the C 2 -C 6  acyl is acetyl.  
     
     
         92 . The method of  claim 89 , wherein R 2 , R 3  and R 4  are each H.  
     
     
         93 . The method of  claim 87 , wherein R 2 , R 3  and R 4  are each H and R 1  is SO 3   − Na + .  
     
     
         94 . The method of  claim 87 , further comprising administering an effective amount of an non-steroidal anti-inflammatory agent.  
     
     
         95 . The method of  claim 79 , wherein the inflammatory lung disorder is asthma or chronic obstructive airway disorder.