Antioxidant combination composition and use thereof

Abstract

An orally or parenterally administrable composition which comprises the following components: (a) L-carnitine inner salt or a pharmacologically acceptable salt thereof, (b) acetyl L-carnitine inner salt or a pharmacologically acceptable salt thereof; (c) α-lipoic acid; (d) coenzyme Q 10 ; (e) Vitamin E: and (i) selenomethionine, suitable for counteracting oxidative stress and use thereof are disclosed.

1 . A combination composition comprising: 
 (a) L-carnitine inner salt or a pharmacologically acceptable salt thereof;    (b) acetyl L-carnitine inner salt or a pharmacologically acceptable salt thereof;    (c) α-lipoic acid;    (d) coenzyme Q 10 ;    (e) Vitamin E; and    (f) selenomethionine.    
     
     
         2 . The composition of  claim 1  in unit dosage form, comprising: 
 (a) 20-110 mg L-carnitine inner salt or an equivalent molar amount of a pharmacologically acceptable salt thereof;    (b) 20-110 mg acetyl L-carnitine inner salt or an equivalent molar amount of a pharmacologically acceptable salt thereof;    (c) 70-130 α-lipoic acid;    (d) 90-110 mg coenzyme Q 10 ;    (e) 5-15 mg Vitamin E; and    (f) 40-60 μg selenomethionine.    
     
     
         3 . The composition of  claim 2 , comprising: 
 (a) 100 mg L-carnitine inner salt;    (b) 100 mg acetyl L-carnitine inner salt;    (c) 100 mg α-lipoic acid;    (d) 100 mg coenzyme Q 10 ;    (e) 10 mg Vitamin E; and    (f) 50 μg selenomethionine.    
     
     
         4 . The composition of claims  1 - 3 , wherein the pharmacologically acceptable salt is selected from the group comprising: chloride; bromide; iodide; aspartate, acid aspartate; citrate, acid citrate; tartrate; phosphate, acid phosphate; fumarate, acid fumarate; galactarate; glycerophosphate; glucose phosphate; lactate; maleate, acid maleate; orotate; oxalate; acid oxalate; sulphate, acid sulphate; trichloroacetate; trifluoroacetate and methane sulphonate.  
     
     
         5 .- 24 . (canceled)