US2005187144A1PendingUtilityA1

Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders

61
Priority: Sep 17, 1998Filed: Jan 25, 2005Published: Aug 25, 2005
Est. expirySep 17, 2018(expired)· nominal 20-yr term from priority
Inventors:Stuart FineKevin Kinsella
A61K 31/555A61K 31/426A61K 31/155A61P 3/08A61K 31/175A61P 3/10A61K 45/06A61K 33/24
61
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Claims

Abstract

Compositions and methods of using the same for the treatment of diabetes and other disorders of glucose metabolism are provided. Compositions may include an anti-diabetic agent and one or more of a bioavailable source of chromium and vanadium.

Claims

exact text as granted — not AI-modified
1 - 96 . (canceled)  
     
     
         97 . A composition comprising synergistic effective amounts of an anti-diabetic agent other than insulin, a bioavailable source of chromium, and a bioavailable source of vanadium, wherein said anti-diabetic agent is a thiazolidinedione, and wherein components of said composition synergistically reduce the hba1c levels of a patient by at least about 10% after treatment for a period of at least about thirty days with said composition as compared to treatment with said anti-diabetic agent alone.  
     
     
         98 . The composition according to  claim 97 , wherein said thiazolidinedione is one of the following: troglitazone, rosiglitazone, or pioglitazone.  
     
     
         99 . The composition of  claim 97 , wherein said reduction in said Hb1Ac level is at least about 50%.  
     
     
         100 . The composition of  claim 97 , wherein said bioavailable source of chromium comprises one or more of chromium picolinate or chromium polynicotinate.  
     
     
         101 . The composition according to  claim 100 , wherein the bioavailable source of chromium is chromium picolinate and wherein the amount of chromium picolinate is from about 30 μg up to about 1000 μg, per dose.  
     
     
         102 . The composition according to  claim 100 , wherein the bioavailable source of chromium is chromium polynicotinate and wherein the amount of chromium polynicotinate is from about 30 μg up to about 5000 μg, per dose.  
     
     
         103 . The composition of  claim 97 , wherein said bioavailable source of chromium comprises no less than about 200 micrograms of elemental chromium.  
     
     
         104 . The composition of  claim 97 , wherein said bioavailable source of chromium comprises no less than about 100 micrograms of elemental chromium.  
     
     
         105 . The composition of  claim 97 , wherein said bioavailable source of chromium comprises no less than about 5 micrograms of elemental chromium.  
     
     
         106 . The composition of  claim 97 , wherein said bioavailable source of vanadium is vanadyl sulfate.  
     
     
         107 . The composition of  claim 106 , wherein the amount of vanadyl sulfate is in the range of about 20 mg up to about 100 mg, per dose.  
     
     
         108 . The composition of  claim 97 , wherein said bioavailable source of vanadium comprises more than about 10 mg elemental vanadium.  
     
     
         109 . The composition of  claim 97 , wherein said amount of said bioavailable source of vanadium comprises no less than 5 mg of elemental vanadium.  
     
     
         110 . The composition according to  claim 97 , wherein said thiazolidinedione is troglitazone.  
     
     
         111 . The composition according to  claim 97 , wherein said thiazolidinedione is rosiglitazone.  
     
     
         112 . The composition according to  claim 97 , wherein said thiazolidinedione is pioglitazone.  
     
     
         113 . The composition according to  claim 100 , wherein said thiazolidinedione is one of the following: troglitazone, rosiglitazone, or pioglitazone.  
     
     
         114 . The composition according to  claim 100 , wherein said thiazolidinedione is troglitazone.  
     
     
         115 . The composition according to  claim 100 , wherein said thiazolidinedione is rosiglitazone.  
     
     
         116 . The composition according to  claim 100 , wherein said thiazolidinedione is pioglitazone.  
     
     
         117 . The composition according to  claim 106 , wherein said thiazolidinedione is one of the following: troglitazone, rosiglitazone, or pioglitazone.  
     
     
         118 . The composition according to  claim 106 , wherein said thiazolidinedione is troglitazone.  
     
     
         119 . The composition according to  claim 106 , wherein said thiazolidinedione is rosiglitazone.  
     
     
         120 . The composition according to  claim 106 , wherein said thiazolidinedione is pioglitazone.  
     
     
         121 . A method for improving glucose metabolism, comprising treating a patient for at least about a thirty day period by administering a pharmaceutical composition comprising synergistic effective amounts of an anti-diabetic agent other than insulin, a bioavailable source of chromium, and a bioavailable source of vanadium, wherein said anti-diabetic agent is a thiazolidinedione, and wherein said components of said composition synergistically reduce the HbA1c level of said patient by at least about 10% after such treatment as compared to treatment with said anti-diabetic agent alone.  
     
     
         122 . The method of  claim 121 , wherein said bioavailable source of chromium comprises no less than about 200 micrograms elemental chromium when said composition is administered on a daily basis.  
     
     
         123 . The method of  claim 121 , wherein said bioavailable source of chromium comprises no less than about 5 micrograms of elemental chromium when said composition is administered on a daily basis.  
     
     
         124 . The method of  claim 121 , wherein said bioavailable source of chromium comprises one or more of chromium picolinate or chromium polynicotinate.  
     
     
         125 . The method of  claim 121 , wherein said bioavailable source of vanadium comprises at least about 10 mg elemental vanadium when said composition is administered on a daily basis.  
     
     
         126 . The method of  claim 121 , wherein said bioavailable source of vanadium is vanadyl sulfate.  
     
     
         127 . The method of  claim 121 , wherein said amount of said bioavailable source of vanadium comprises no less than 5 mg of elemental vanadium when said composition is administered on a daily basis.  
     
     
         128 . The method of  claim 121 , wherein said thiazolidinedione is one of the following: troglitazone, rosiglitazone, or pioglitazone.  
     
     
         129 . The method of  claim 121 , wherein said thiazolidinedione is troglitazone.  
     
     
         130 . The method of  claim 121 , wherein said thiazolidinedione is rosiglitazone.  
     
     
         131 . The method of  claim 121 , wherein said thiazolidinedione is pioglitazone.  
     
     
         132 . The method of  claim 121 , wherein said pharmaceutical composition further comprises a physiologically acceptable carrier.  
     
     
         133 . The method of  claim 121 , wherein said method further comprises monitoring said subject's HbA1c levels.  
     
     
         134 . The method of  claim 121 , wherein said reduction in said Hb1Ac level is at least about 50%.

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