Antioxidant combination composition and use thereof

Abstract

An orally or parenterally administrable composition which comprises the following components: (a) L-carnitine inner salt or a pharmacologically acceptable salt thereof, (b) acetyl L-carnitine inner salt or a pharmacologically acceptable salt thereof; (c) α-lipoic acid; (4) coenzyme Q 10 ; (e) Vitamin E; and (f) selenomethionine, suitable for counteracting oxidative stress and use thereof are disclosed.

1 - 9 . (canceled)  
     
     
         10 . A therapeutical method for preventing and/or treating a disorder or disease brought about by oxidative stress, untimely early physiological apoptotic phenomena following oxidative stress and/or environmental agent-induced apoptosis which comprises administering to a patient in need thereof an effective amount of a combination composition comprising: 
 (a) L-carnitine inner salt or a pharmacologically acceptable salt thereof;    (b) acetyl L-carnitine inner salt or a pharmacologically acceptable salt thereof;    (c) α-lipoic acid;    (d) coenzyme Q 10 ;    (e) Vitamin E; and    (f) selenomethionine.    
     
     
         11 . The therapeutical method of  claim 10  which comprises administering to said patient, on a multiple dose administration regimen, a composition which, in unit dosage form, comprises: 
 (a) 20-110 mg L-carnitine inner salt or an equivalent molar amount of a pharmacologically acceptable salt;    (b) 20-110 mg acetyl L-carnitine inner salt or an equivalent molar amount of a pharmacologically acceptable salt thereof;    (c) 70-130 mg α-lipoic acid;    (d) 90-110 mg coenzyme Q 10 ;    (e) 5-15 mg Vitamin E; and    (f) 40-60 μg selenomethionine.    
     
     
         12 . (canceled)  
     
     
         13 . The therapeutical method of  claim 11  for preventing or treating atherosclerosis.  
     
     
         14 . The therapeutical method of  claim 11  for preventing or treating ischaemia-reperfusion injuries.  
     
     
         15 . The therapeutical method of  claim 11  for preventing or treating rheumatoid arthritis.  
     
     
         16 . The therapeutical method of  claim 11  for preventing or treating cancer.  
     
     
         17 . The therapeutical method of  claim 11  for preventing or treating stroke.  
     
     
         18 . The therapeutical method of  claim 11  for preventing or treating cataract and other eye diseases.  
     
     
         19 . The therapeutical method of  claim 11  for preventing or treating thyroid diseases.  
     
     
         20 . The therapeutical method of  claim 11  for preventing or treating liver diseases.  
     
     
         21 . The therapeutical method of  claim 11  for preventing or treating sexual impotence.  
     
     
         22 . The therapeutical method of  claim 11  for preventing or treating Parkinson's disease.  
     
     
         23 . The therapeutical method of  claim 11  for preventing or treating Alzheimer's disease.  
     
     
         24 . The therapeutical method of  claim 11  for preventing or treating degenerative disorders affecting virus-infected patients.