US2005182017A1PendingUtilityA1
Immunostimulatory nucleic acid molecules
Est. expiryOct 30, 2017(expired)· nominal 20-yr term from priority
Inventors:Arthur M. Krieg
A61P 37/04A61P 31/00A61P 37/06A61P 43/00A61P 35/00A61P 31/04A61P 31/12A61P 37/02A61P 33/00A61P 37/08C12N 2310/315C12N 2310/17C07H 21/00A61K 31/711A61P 1/02A61K 31/7125A61P 1/04C12Q 1/68A61K 31/00A61P 17/06A61K 2039/55561A61K 31/7048A61P 19/02A61P 11/06A61P 1/00A61K 39/39C12N 15/117A61K 31/4706C07H 21/04A61K 39/00
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Claims
Abstract
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
Claims
exact text as granted — not AI-modified1 - 41 . (canceled)
42 . An oligonucleotide comprising TCGTCGTTTTGTCGTTTTGTCGTT (SEQ ID No. 46).
43 . The oligonucleotide of claim 42 , wherein at least one nucleotide has a phosphate backbone modification.
44 . The oligonucleotide of claim 42 , wherein the oligonucleotide has less than or equal to 100 nucleotides.
45 . The oligonucleotide of claim 42 , wherein the oligonucleotide has a sequence consisting of TCGTCGTTTTGTCGTTTTGTCGTT (SEQ ID No. 46).
46 . The oligonucleotide of claim 43 , wherein the phosphate backbone modification is a phosphorothioate or phosphorodithioate modification.
47 . A method for stimulating an immune response, comprising administering to a subject the oligonucleotide of claim 42 in an effective amount to stimulate an immune response.
48 . The method of claim 47 , wherein the subject has or is at risk of developing cancer.
49 . The method of claim 47 , wherein the subject has or is at risk of developing infectious disease.
50 . A method for stimulating an immune response, comprising administering to a subject the oligonucleotide of claim 45 in an effective amount to stimulate an immune response.
51 . The method of claim 50 , wherein the subject has or is at risk of developing cancer.
52 . The method of claim 50 , wherein the subject has or is at risk of developing infectious disease.Join the waitlist — get patent alerts
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