Anti-inflammatory nitro-and thia-fatty acids
Abstract
The present invention relates to compounds of the general formula: NO 2 -A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH 2 ) n (COOH) m in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or of general formula (I), wherein A′ is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and B′ is (CH 2 ) j (COOH) k in which j is an integer from 1 to 3 and k is 0 or 1; and the derivatives thereof in which the hydrocarbon chain includes one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy. These compounds have biological activity, e.g. as anti-infective or anti-inflammatory agents.
Claims
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74 . An anti-infective pharmaceutical composition comprising a compound having the general formula:
wherein A is an unsaturated hydrocarbon chain of 14 to 26 carbon atoms or a derivative thereof selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy; and B is (CH 2 ) n (COOH) m in which n is an integer from 0 to 2 and m is 1 or 2; wherein the NO 2 group is a side group on any one of the carbon atoms of A and a pharmaceutically acceptable carrier or diluent.
75 . A composition according to claim 74 wherein the unsaturated hydrocarbon chain comprises 18 to 22 carbon atoms.
76 . A composition according to claim 74 wherein the unsaturated hydrocarbon chain comprises 3 to 6 double bonds.
77 . A composition according to claim 74 wherein the hydrocarbon chain comprises 18 carbon atoms and three double bonds separated by methylene groups, with the first double bond between the 3 rd and 4 th or 6 th and 7 th carbon atoms relative to the omega carbon atom.
78 . A composition according to claim 74 effective for treating malaria.
79 . An composition according to claim 74 effective for treating malaria caused by a parasite selected from the group consisting of Plasmodium falciparum or Plasmodium vivax.
80 . A method for treating an infection in a subject comprising administering to the subject a therapeutic amount of a composition of claim 1 .
81 . A method according to claim 80 wherein the infection is caused by a malaria parasite.
82 . A method according to claim 81 wherein the malaria parasite is Plasmodium falciparum or Plasmodium vivax.Join the waitlist — get patent alerts
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