Treatment of autoimmune diseases, including AIDS

Abstract

The present disclosure concerns the treatment of a patient with autoimmune disease, including AIDS, by neutralizing, removing or inhibiting different types of interferons, tumor necrosis factor, HLA class II antigens, IgE, and other pathological factors and/or their receptors, as well as neutralizing, removing or inhibiting autoantibodies, including antibodies to target cells, CD4 cells and DNA. Treatment comprises administration of an autoimmune inhibitor, or extracorporeal exposure of the patient's fluid to an immunosorbent comprising an autoimmune inhibitor, followed by return of the treated fluid to the patient; or it comprises a combined therapy involving extracorporeal immunosorption in conjunction with the administration of an autoimmune inhibitor.

1 - 32 . (canceled)  
     
     
         33 . A method of treating Acquired Immunodeficiency Disease in a patient comprising administering to said patient an effective amount of a plurality of two autoimmune inhibitors selected from the group consisting of an antibody to alpha interferon, an antibody to gamma interferon, and an antibody to tumor necrosis factor alpha.  
     
     
         34 . The method of  claim 33 , wherein said plurality of autoimmune inhibitors comprises (a) an antibody to alpha interferon and an antibody to tumor necrosis factor alpha, or an (b) an antibody to gamma interferon and an antibody to tumor necrosis factor alpha.  
     
     
         35 - 36 . (canceled)  
     
     
         37 . The method of  claim 33 , wherein said antibody is selected from the group consisting of a monoclonal antibody, a polyclonal antibody, a human antibody a humanized antibody, a biologically active fragment thereof, and combinations thereof.  
     
     
         38 - 41 . (canceled)  
     
     
         42 . A kit for treating Acquired Immunodeficiency Disease in a patient, said kit comprising an effective amount of a plurality of two autoimmune inhibitors selected from the group consisting of an antibody to alpha interferon, an antibody to gamma interferon, an antibody to tumor necrosis factor alpha, an applicator and an instructional material for the use thereof.  
     
     
         43 . The kit of  claim 42 , wherein said antibody is selected from the group consisting of a monoclonal antibody, a polyclonal antibody, a human antibody, a humanized antibody and combinations thereof.