US2005171002A1PendingUtilityA1
Polyoxyalkylene compound and method for making
Priority: Feb 3, 2004Filed: Feb 3, 2004Published: Aug 4, 2005
Est. expiryFeb 3, 2024(expired)· nominal 20-yr term from priority
C07C 229/16C07C 251/24C07C 229/14
46
PatentIndex Score
0
Cited by
0
References
0
Claims
Abstract
A process for forming a conjugate of a polyoxyalkylene polymer (such as polyethylene glycol) with a compound containing an amine group(s) and/or a sulfide group(s) by reacting the compound with an acrylate terminated polyoxyalkylene (such as polyethylene glycol terminate at one end with acrlyate or methacrylate and terminated at the other end with a methoxy group). The reaction is believed to be a Michael addition. When the compound contains primary amine groups (such as the surface primary amine groups of a PAMAM dendrimer), it is usually desirable to convert the primary amine groups to secondary amine groups before the reaction with the acrylate terminated polyoxyalkylene.
Claims
exact text as granted — not AI-modified1 . A compound corresponding to the formula:
where R 1 is an organic radical
where R 2 is H or an organic radical
where R 3 is H or an organic radical
where R 4 is a polyoxyalkylene radical and where R 5 is an organic radical or H.
2 . The compound of claim 1 , wherein R 1 is derived from a dendrimer.
3 . The compound of claim 1 , wherein R 1 is selected from the group consisting of a group derived from a peptide or a protein.
4 . The compound of claim 1 , wherein R 4 is derived from polyethylene glycol.
5 . The compound of claim 2 , wherein R 2 is derived from a cyclodextrin, wherein R 3 is H, wherein R 4 is derived from polyethylene glycol and wherein R 5 is CH 3 .
6 . The compound of claim 3 , wherein R 2 is derived from a cyclodextrin, wherein R 3 is H, wherein R 4 is derived from polyethylene glycol and wherein R 5 is CH 3 .
7 . The compound of claim 3 , wherein R 2 is H, wherein R 3 is H, wherein R 4 is derived from polyethylene glycol and wherein R 5 is CH 3 .
8 . A compound corresponding to the formula:
where R 6 is an organic radical
where R 7 is H or an organic radical
where R 8 is a polyoxyalkylene radical
and where R 9 is an organic radical or H.
9 . The compound of claim 8 , wherein R 6 is selected from the group consisting of a group derived from a peptide or a protein.
10 . The compound of claim 8 , wherein R 6 is derived from polyethylene glycol.
11 . The compound of claim 9 , wherein R 7 is H, wherein R 8 is derived from polyethylene glycol and wherein R 9 is CH 3 .
12 . A method for preparing a compound corresponding to the formula:
where R 1 is an organic radical
where R 2 is H or an organic radical
where R 3 is H or an organic radical
where R 4 is a polyoxyalkylene radical
and where R 5 is an organic radical or H, comprising the step of: reacting A with B, wherein A is R 1 —N—R 2 and wherein
13 . The process of claim 12 , wherein R 1 is derived from a dendrimer.
14 . The process of claim 12 , wherein R 1 is selected from the group consisting of a group derived from a peptide or a protein.
15 . The process of claim 12 , wherein R 4 is derived from polyethylene glycol.
16 . The process of claim 13 , wherein R 2 is derived from a cyclodextrin, wherein R 3 is H, wherein R 4 is derived from polyethylene glycol and wherein R 5 is CH 3 .
17 . The process of claim 14 , wherein R 2 is derived from a cyclodextrin, wherein R 3 is H, wherein R 4 is derived from polyethylene glycol and wherein R 5 is CH 3 .
18 . The process of claim 14 , wherein R 2 is H, wherein R 3 is H, wherein R 4 is derived from polyethylene glycol and wherein R 5 is CH 3 .
19 . A method for preparing a compound corresponding to the formula:
where R 6 is an organic radical
where R 7 is H or an organic radical
where R 8 is a polyoxyalkylene radical
and where R 9 is an organic radical or H, comprising the step of: reacting D with E, wherein D is R 6 —S and wherein E is
20 . The compound of claim 19 , wherein R 6 is selected from the group consisting of a group derived from a peptide or a protein.
21 . The compound of claim 19 , wherein R 8 is derived from polyethylene glycol.
22 . The compound of claim 20 , wherein R 7 is H, wherein R 8 is derived from polyethylene glycol and wherein R 9 is CH 3 .Join the waitlist — get patent alerts
Track US2005171002A1 — get alerts on status changes and closely related new filings.
We store only your email — no account needed. See our privacy policy.