US2005170403A1PendingUtilityA1

Combinatorial enzymatic complexes

56
Assignee: RIGEL PHARMACEUTICALS INCPriority: Jun 12, 1997Filed: Jan 28, 2005Published: Aug 4, 2005
Est. expiryJun 12, 2017(expired)· nominal 20-yr term from priority
Inventors:Garry P. NolanDonald Payan
C12N 15/1044C12N 15/1075C12P 1/00C12N 15/1034C12N 15/1062C12N 15/1079C12N 2799/027
56
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Claims

Abstract

The invention relates to the formation of novel in vivo combinatorial enzyme complexes for use in screening candidate drug agents for bioactivity.

Claims

exact text as granted — not AI-modified
1 - 26 . (canceled)  
     
     
         27 . A library of cells comprising: 
 a) nucleic acid encoding an exogenous scaffold comprising a first binding site and a second binding site; and    b) nucleic acid encoding a first enzyme and a second enzyme,    wherein at least one of said enzymes is heterologous to said cells; and    wherein said first enzyme binds to said first binding site and said second enzyme binds to said second binding site.    
     
     
         28 . The library of cells of  claim 27 , wherein said cells are tumor cells.  
     
     
         29 . The library of cells of  claim 27 , wherein said cells contain an infectious agent.  
     
     
         30 . The library of cells of  claim 27 , wherein said cells are immune system cells.  
     
     
         31 . The library of cells of  claim 27 , wherein said cells contain a virus.  
     
     
         32 . The library of cells of  claim 27 , wherein said cells are mammalian cells.  
     
     
         33 . The library of cells of  claim 27 , wherein said scaffold is linear.

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