US2005162657A1PendingUtilityA1

Optical resonance analysis system

Assignee: APPLERA CORPPriority: Dec 12, 1997Filed: Mar 7, 2005Published: Jul 28, 2005

Est. expiryDec 12, 2017(expired)· nominal 20-yr term from priority

Inventors:Dar Bahatt Jerry E. Cahill Koichi Nishikida Enrico Picozza Paul G. Saviano David H. Tracy Yongdong Wang

G01N 21/7703G01N 21/553

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References

Claims

Abstract

An optical resonance analysis system comprising a sensor means ( 60 ) and an illumination means ( 400 ) for generating non-monochromatic illumination. The illumination means ( 400 ) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles ( 390 ) and a dispersive device ( 380 ) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean ( 60 ) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means ( 90 ) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means ( 120 ).

Claims

exact text as granted — not AI-modified

1 . An optical resonance analysis system comprising:
illumination means for generating illumination of fixed multiple wavelengths further comprising:
an array of elements each generating a different fixed wavelength; and
an optical system which projects said illumination of fixed wavelengths;
sensor means on which said illumination impinges which reflects or transmits said illumination; and, detection means for detecting said reflected or transmitted illumination.

2 . The optical resonance analysis system of claim 1 wherein said sensor means further comprises a surface plasmon resonance device.

3 . The optical resonance analysis system of claim 1 wherein said sensor means further comprises a waveguide device.

4 . The optical resonance analysis system of claim 1 wherein said sensor means further comprises a multi-layered waveguide device.

5 . The optical resonance analysis system of claim 1 wherein said sensor means is arranged as a one dimensional array of analysis sites.

6 . The optical resonance analysis system of claim 1 wherein said sensor means is arranged as a two dimensional array of analysis sites.

7 . The optical resonance analysis system of claim 1 wherein said detector means further comprises a charge coupled device camera.

8 . The optical resonance analysis system of claim 1 wherein said detector means further comprises a charge injection device camera.

9 . The optical resonance analysis system of claim 1 wherein said detector means further comprises an angle stop.

10 . The optical resonance analysis system of claim 1 wherein said detector means further comprises a wavelength stop.

11 . The optical resonance analysis system of claim 1 wherein said detector means further comprises an imaging lens.

12 . The optical resonance analysis system of claim 1 wherein said detector means further comprises a polarizer.

13 . An optical resonance analysis system comprising:
illumination means for generating illumination of varying angles further comprising:
a source comprised of an array of elements for generating illumination at a pluralty of fixed angles; and
a lens system for projecting said illumination at said plurality of fixed angles;
sensor means on which said illumination impinges which reflects or transmits said illumination; and, detection means for detecting said reflected or transmitted illumination.

14 . The optical resonance analysis system of claim 13 wherein said sensor means further comprises a surface plasmon resonance device.

15 . The optical resonance analysis system of claim 13 wherein said sensor means further comprises a waveguide device.

16 . The optical resonance analysis system of claim 13 wherein said sensor means further comprises a multi-layered waveguide device.

17 . The optical resonance analysis system of claim 13 wherein said sensor means is arranged as a one dimensional array of analysis sites.

18 . The optical resonance analysis system of claim 13 wherein said sensor means is arranged as a two dimensional array of analysis sites.

19 . The optical resonance analysis system of claim 13 wherein said detector means further comprises a charge coupled device camera.

20 . The optical resonance analysis system of claim 13 wherein said detector means further comprises a charge injection device camera.

21 . The optical resonance analysis system of claim 13 wherein said detector means further comprises an angle stop.

22 . The optical resonance analysis system of claim 13 wherein said detector means further comprises a wavelength stop.

23 . The optical resonance analysis system of claim 13 wherein said detector means further comprises an imaging lens.

24 . The optical resonance analysis system of claim 13 wherein said detector means further comprises a polarizer.

25 . An optical resonance analysis system comprising:
sensor means; illumination means for generating non-monochromatic illumination having a plurality of wavelengths further comprising:
means for generating illumination at a plurality of angles;
a lens system for projecting said illumination at said plurality of angles; and
a dispersive device for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor means for all wavelengths generated by said non-monochromatic source simultaneously;
detection means for detecting said reflected or transmitted illumination.

26 . The optical resonance analysis system of claim 25 wherein said sensor means further comprises a surface plasmon resonance device.

27 . The optical resonance analysis system of claim 25 wherein said sensor means further comprises a waveguide device.

28 . The optical resonance analysis system of claim 25 wherein said sensor means further comprises a multi-layered waveguide device.

29 . The optical resonance analysis system of claim 25 wherein said sensor means is arranged as a one dimensional array of analysis sites.

30 . The optical resonance analysis system of claim 25 wherein said sensor means is arranged as a two dimensional array of analysis sites.

31 . The optical resonance analysis system of claim 25 wherein said detector means further comprises a charge coupled device camera.

32 . The optical resonance analysis system of claim 25 wherein said detector means further comprises a charge injection device camera.

33 . The optical resonance analysis system of claim 25 wherein said detector means further comprises an angle stop.

34 . The optical resonance analysis system of claim 25 wherein said detector means further comprises a wavelength stop.

35 . The optical resonance analysis system of claim 25 wherein said detector means further comprises an imaging lens.

36 . The optical resonance analysis system of claim 25 wherein said detector means further comprises a polarizer.

37 . An optical resonance analysis system comprising:
illumination means for generating illumination further comprising:
a source; and
positioning means for independently positioning said source rotationally and axially;
sensor means on which said illumination impinges which reflects or transmits said illumination; and, detection means for detecting said reflected or transmitted illumination.

38 . The optical resonance analysis system of claim 37 wherein said sensor means further comprises a surface plasmon resonance device.

39 . The optical resonance analysis system of claim 37 wherein said sensor means further comprises a waveguide device.

40 . The optical resonance analysis system of claim 37 wherein said sensor means further comprises a multi-layered waveguide device.

41 . The optical resonance analysis system of claim 37 wherein said sensor means is arranged as a one dimensional array of analysis sites.

42 . The optical resonance analysis system of claim 37 wherein said sensor means is arranged as a two dimensional array of analysis sites.

43 . The optical resonance analysis system of claim 37 wherein said detector means further comprises a charge coupled device camera.

44 . The optical resonance analysis system of claim 37 wherein said detector means further comprises a charge injection device camera.

45 . The optical resonance analysis system of claim 37 wherein said detector means further comprises an angle stop.

46 . The optical resonance analysis system of claim 37 wherein said detector means further comprises a wavelength stop.

47 . The optical resonance analysis system of claim 37 wherein said detector means further comprises an imaging lens.

48 . The optical resonance analysis system of claim 37 wherein said detector means further comprises a polarizer.

49 . The optical resonance analysis system of claim 37 wherein said positioning means further comprises:
a housing; rotation means for rotating said source a cylinder having pseudo-helical slots; and pins extending from said rotation means to engage said pseudo-helical slots.

50 . Positioning means for independently positioning an item rotationally and axially comprising:
a housing; rotation means for rotating said source a cylinder having pseudo-helical slots; and pins extending from said rotation means to engage said pseudo-helical slots.

51 . An optical resonance analysis system comprising:
illumination means for generating illumination; anamorphic imaging means sensor means on which said illumination impinges which reflects or transmits said illumination; and, detection means for detecting said reflected or transmitted illumination.

52 . The optical resonance analysis system of claim 1 wherein said sensor means further comprises a surface plasmon resonance device.

53 . The optical resonance analysis system of claim 1 wherein said sensor means further comprises a waveguide device.

54 . The optical resonance analysis system of claim 1 wherein said sensor means further comprises a multi-layered waveguide device.

55 . The optical resonance analysis system of claim 1 wherein said sensor means is arranged as a one dimensional array of analysis sites.

56 . The optical resonance analysis system of claim 1 wherein said sensor means is arranged as a two dimensional array of analysis sites.

57 . The optical resonance analysis system of claim 1 wherein said detector means further comprises a charge coupled device camera.

58 . The optical resonance analysis system of claim 1 wherein said detector means further comprises a charge injection device camera.

59 . The optical resonance analysis system of claim 1 wherein said detector means further comprises an angle stop.

60 . The optical resonance analysis system of claim 1 wherein said detector means further comprises a wavelength stop.

61 . The optical resonance analysis system of claim 1 wherein said detector means further comprises an imaging lens.

62 . The optical resonance analysis system of claim 1 wherein said detector means further comprises a polarizer.

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