Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolferative diseases

Abstract

Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders.

1 - 70 . (canceled)  
     
     
         71 . A method for treating cancer which comprises administering to a mammal an amount of Compound (1), having the formula,  
       
         
           
           
               
               
           
         
       
       and at least one anti Her-2 antibody, wherein the combination of Compound 1 and the at least one anti Her-2 antibody is therapeutically-effective.  
     
     
         72 . The method of  claim 71  wherein the at least one anti Her-2 antibody is HERCEPTIN™.  
     
     
         73 . The method of  claim 71 , wherein the cancer is breast cancer.  
     
     
         73 . The method of  claim 71 , wherein the cancer is prostate cancer.  
     
     
         74 . The method of  claim 71 , wherein the cancer is lung cancer.  
     
     
         75 . The method of  claim 71 , wherein the cancer is refractory to taxane treatment.  
     
     
         76 . The method of  claim 75 , wherein the cancer is innately refractory to taxane treatment.  
     
     
         77 . The method of  claim 71 , wherein the Compound 1 is administered before the at least one anti Her-2 antibody.  
     
     
         78 . The method of  claim 71 , wherein the Compound 1 is administered after the anti Her-2 antibody.  
     
     
         79 . The method of  claim 71 , wherein the Compound 1 is administered simultaneously with the anti Her-2 antibody.  
     
     
         80 . A pharmaceutical product for treating cancer in a patient, the product comprising a combination product comprising an amount of Compound (1), which is,  
       
         
           
           
               
               
           
         
       
       and at least one anti Her-2 antibody.  
     
     
         81 . The product of claim  8 Q wherein the anti Her-2 antibody is HERCEPTIN™.  
     
     
         82 . A method for treating cancer which comprises administering to a mammal an amount of Compound (1), having the formula,  
       
         
           
           
               
               
           
         
       
       and at least one anti Her-2 antibody, wherein the combination of Compound 1 and the at least one anti Her-2 antibody is synergistically-effective.  
     
     
         83 . The method of  claim 82  wherein the at least one anti Her-2 antibody is HERCEPTIN™.  
     
     
         84 . The method of  claim 82 , wherein the cancer is breast cancer.  
     
     
         85 . The method of  claim 82 , wherein the cancer is prostate cancer.  
     
     
         86 . The method of  claim 82 , wherein the cancer is lung cancer.  
     
     
         87 . The method of  claim 82 , wherein the cancer is refractory to taxane treatment.  
     
     
         88 . A kit for treating cancer in a patient, the kit comprising in a first package an amount of Compound (1), which is,  
       
         
           
           
               
               
           
         
       
       and in a second package, an anti Her-2 antibody, wherein the administration of the Compound 1 and the anti Her-2 antibody is synergistically effective.  
     
     
         89 . The kit of  claim 88  wherein the anti Her-2 antibody is HERCEPTIN™.  
     
     
         90 . The method of  claim 72  further comprising the co-administration of tamoxifen.