Nucleic acids of the human ABCC11 gene, vectors containing such nucleic acids and uses thereof

Abstract

The present invention relates to nucleic acids corresponding to various exons of the ABCC11 gene as well as the cDNA encoding the novel full length of ABCC11 protein. The invention also relates to means for the detection of polymorphisms in general, and of mutations in particular, in the ABCC11 gene or in the corresponding protein produced by the allelic form of the ABCC11 gene.

1 - 24 . (canceled)  
     
     
         25 . An isolated polypeptide selected from the group consisting of 
 a) a polypeptide comprising an amino acid sequence of SEQ D NO:31,    b) a polypeptide fragment or variant of a polypeptide comprising an amino acid sequence of SEQ ID NO:31, and    c) a polypeptide homologous to a polypeptide comprising an amino acid sequence of SEQ ID NO:31:    
     
     
         26 . An antibody directed against the isolated polypeptide according to  claim 25 .  
     
     
         27 . The antibody according to  claim 26 , wherein the antibody comprises a detectable compound.  
     
     
         28 . A method of detecting a polypeptide, comprising: 
 a) contacting the polypeptide with an antibody according to  claim 26;  and    b) detecting an antigen/antibody complex formed between the polypeptide and the antibody.    
     
     
         29 . A diagnostic kit for detecting a polypeptide, comprising: 
 a) the antibody according to  claim 26;  and    b) a reagent allowing detection of an antigen/antibody complex formed between the polypeptide and the antibody.    
     
     
         30 - 34 . (canceled)  
     
     
         35 . A pharmaceutical composition comprising a polypeptide comprising an amino acid sequence of the SEQ ID NO:31, and a physiologically compatible excipient.  
     
     
         36 - 40 . (canceled)