68999, a human ubiquitin carboxyl-terminal hydrolase family member and uses therefor

Abstract

The invention provides isolated nucleic acids molecules, designated 68999 nucleic acid molecules, which encode novel ubiquitin carboxyl-terminal hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 68999 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 68999 gene has been introduced or disrupted. The invention still further provides isolated 68999 proteins, fusion proteins, antigenic peptides and anti-68999 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

1 - 29 . (canceled)  
     
     
         30 . An isolated polypeptide selected from the group consisting of: 
 a) a polypeptide comprising the amino acid sequence of SEQ ID NO:2;    b) a. polypeptide consisting of the amino acid sequence of SEQ ID NO:2; and    c) a polypeptide which is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3    
     
     
         31 . An isolated polypeptide selected from the group consisting of: 
 a) a polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3; and    b) a polypeptide comprising an amino acid sequence which is at least 95% identical to the amino acid sequence of SEQ ID NO:2;    wherein the polypeptide has hydrolase activity.    
     
     
         32 . The polypeptide of  claim 30 , further comprising a heterologous amino acid sequence.  
     
     
         33 . The polypeptide of  claim 31 , further comprising a heterologous amino acid sequence.