Composition of insulin for nasal administration

Abstract

Provided is an insulin-containing granulated composition for nasal administration comprising a crystalline cellulose aggregate having a specific particle diameter distribution as a carrier. Such granulated composition for nasal administration can efficiently increase a blood insulin concentration.

1 - 5 . (canceled)  
     
     
         6 . A granulated composition for nasal administration composed of powdered insulin and its carrier, aggregated crystalline cellulose, the distinguishing features of which are that the said insulin is soluble, and that 85 w/w % or more of said crystalline cellulose aggregate has a cribriform particle diameter range of 20-60 μm in one part or across the whole area, and the said granulated composition has a particle diameter falling substantially within the range of that prescribed for the said crystalline cellulose aggregate.  
     
     
         7 . The composition as described in  claim 6  having a cribriform particle diameter range distributions of: 
 w/w % or less of particle diameters below 25 μm,    20-60 w/w % of particle diameters of 25-38 μm,    20-60 w/w % of particle diameters greater than 38 μm and up to 53 μm, and    10 w/w % or less of particle diameters exceeding 53 μm, taking the entire particle as 100%.    
     
     
         8 - 14 . (canceled)