Substituted chiral allosteric hemoglobin modifiers

Abstract

A family of substituted chiral allosteric effectors of hemoglobin is useful for delivering more oxygen to hypoxic and ischemic tissues by reducing the oxygen affinity of hemoglobin in whole blood.

1 - 32 . (canceled)  
     
     
         33 . An isolated positive isomer of the compound 2-[4-[[(3,5-dimethylanilino) carbonyl]methyl]phenoxyl]-2-methylproprionic acid.  
     
     
         34 . The isolated positive isomer of  claim 33 , wherein the isomer is purified.  
     
     
         35 . A pharmaceutical composition comprising the isolated positive isomer of  claim 33 .  
     
     
         36 . A method of allosterically modifying hemoglobin, comprising administering to a patient the isolated positive isomer of  claim 33 .  
     
     
         37 . A method of treating a disease state in which tissues suffer from low oxygen tension, comprising administering to a patient in need thereof the isolated positive isomer of  claim 33 .  
     
     
         38 . The method of  claim 37 , wherein the disease state is selected from the group consisting of cancer, ischemia, peripheral vascular disease, coronary occlusion, cerebral vascular accidents, tissue transplant, Alzhiemer's disease, depression, and schizophrenia.  
     
     
         39 . A method of treating a disease state, comprising administering to a patient in need thereof the isolated positive isomer of  claim 33 , wherein the disease state is selected from the group consisting of hypothermia, hypoxia induced myocardial damage, hemorrhagic shock, wounds, diabetic ulcers, chronic leg ulcers, pressure sores, stroke, blocked arteries, angina, and acute respiratory distress syndrome.  
     
     
         40 . A method of treating tumors: 
 a) contacting the tumor with the isolated positive isomer of  claim 33  to deliver oxygen to the tumor; and    b) administering radiation to the tumor.